pharm - ch 73 - gout
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| gout is usually, but not always characterized by | hyperuricemia
🗑
|
||||
| acute episodes are ALWAYS characterized by | urate crystals in joint fluid
🗑
|
||||
| what causes hyperuricemia/urate crystals | excessive production of uric acid-----impaired renal excretion of uric acid
🗑
|
||||
| Acute tx of gout includes tx for pain, inflammation using these 3 classes of drugs | anti-inflam/cholchicine----NSAIDs---corticosteroids
🗑
|
||||
| PREVENTION of gout bwo 2 mechanisms | decrease prodcution of uric acid---increase excretion (uricosuric)
🗑
|
||||
| anti-inflamm agent to treat ACUTE gouty attack while offering some bridging to prevent subsequent attack | colchicine - oral
🗑
|
||||
| We only give colchicine for 2 doses - why | wicked GI SEs n/v/DIARRHEA----rare nephrotoxicity
🗑
|
||||
| name 2 drugs that are for chronic use/preventative ---lower uric acid levels | allopurinol---febuxostat
🗑
|
||||
| MOA of drugs to lower uric acid = allopurinol, febuxostat | inhibit xanthine oxidase so it can't convert purines to uric acid
🗑
|
||||
| are drugs to lower uric acid preventative? | yes, if there's less uric acid, then we are preventing goit
🗑
|
||||
| why don't we use febuxostat as often | $$$ but it works same as allopurinol
🗑
|
||||
| ADRs allopurinol | gen well tolerated-----Rare----hypersensitivity syndrome = rash/fever/eosinophilia/liver/kidney dysfunciton----cataracts-----GI,HA
🗑
|
||||
| ADRs febuxostat | same as allopurinol except no dermatological hypersensitivity
🗑
|
||||
| name 2 uricosurics that increase urinary excretion of uric acid | probenecid-----sulfinpyrazone
🗑
|
||||
| why use uricosurics | only for PREVENTION of attacks----NO BENEFIT for acute gouty attack
🗑
|
||||
| ADRs/class of probenecid and sulfinpyrazone | uricosurics with these ADRs---risk of nephrolithiasis---PT MUST DRINK 2-3 LITERS OF WATER PER DAY ---GI---hypersensitivity reactions
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
lorrelaws
Popular Nursing sets