LECOM Pharm Ch 28 Reproductive
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| GnRH receptor agonist used to stimulate ovulation and test for hypogonadism | Gonadarelin
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| GnRH receptor antagonist (2) | cetrorelix, ganirelix
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| GnRH receptor agonists used in Breast/prostate CA, endometriosis etc (4) | Goserelin, Histrelin, Leuprolide, Nafarelin
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| GnRH agonist that can cause pituitary apoplexy | leuprolide
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| 2 GnRH agonists that can cause DVT | goserelin, leuprolide
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| 2 GnRH antagonists that are used to induce ovulation | ganirelix and Cetrorelix
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| GnRH antagonist that can cause spontaneous abortions | ganirelix
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| GnRH antagonist that can cause anaphylaxis | cetrorelix
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| How to inhibit LH and FSH release | constant GnRH agonist
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| How to stimulate LH and FSH release | intermittent GnRH agonists
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| Used for BPH and androgenic alopecia | finasteride
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| MOA of finasteride | inhibits type II 5α-reductase
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| 2 irreversable aromatase inhibitors | Formestane and exemestane
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| 2Reversable aromatase inhibitors | anastrozole and letrozole
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| 4 serious SE of aromatase inhibitors | osteoporotic Fx, hypercholesterolemia, profuse vaginal bleeding, thrombophlebitis
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| Drug used for infertility secondary to ovulatory disorder | clompiphene
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| Estrogen receptor antagonist in the breast with partial agonist in endometrium and bone | tamoxifen
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| MOA of clomiphene | estrogen receptor antagonist in hypothalamus, anterior pituitary, partial in ovaries
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| Estrogen receptor agonist in bone and antagonist in uterus and breast |
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| SERM that can cause CVA | tamoxifen
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| Used in post menopausal women w/ non-responsive anti-estrogen Tx breast cancer | fulvestrant
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| Estrogen receptor antagonist with no agonist activity | fulvestrant
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| MOA of Flutamide | competitive inhibitor of androgen receptor
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| Used with metastatic prostate cancer or BPH, best with castration | Flutamide
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| MOA of spironolactone | aldosterone and androgen receptor antagonist
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| MOA of Mifepristone | progesterone antagonist
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| Used for abortion | mifepristone/RU-486
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| 2 progestins with highest androgenic effects | norgestril and levonorgestril
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| Synthetic progestin with anti-androgenic action | drosperinone
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| Used in the “morning after” pill | levonorgestrel
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| What drug is used with a silastic implant good for 3 years of birth control | etonogestrel
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| Can be given parenterally ever 3 months for birth control | Medroxyprogesterone acetate
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| Used as progestin-only contraceptive (2) orally available | Norgestrel, norethindrone
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