LECOM Pharm 32 Abx DNA translation transcription
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each of the black spaces below before clicking
on it to display the answer.
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| Mnemonic for 50s vs 30s inhibitors and what they stand for | CLEan TAG: Clinda/Chloramphenicol, Linezolid, Erythro, Tetra/Tigecycline, AG= aminoglycosides
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| Ending and MOA of quinolones | -floxacin; Topoisomerase II inhibitors
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| What do you used quinolones to treat | gram negatives
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| 6 SE of Quinalones | cartilage/tendon rupture, peripheral neuropathy, increased ICP, seizure, sever hypersensitivity reactions
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| MOA of rifampin and rifabutiin | bind bacterial DNA dependant RNA polymerase
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| Used for meningitis prophylaxis | rifampin
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| 2 SE of rifampin.rifabutin | thrombocytopenia and hepatotoxicity
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| Group of Abx that is bactericidal causing mRNA misreads | Aminoglycosides
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| Use AG to treat? | serious gram negative bugs
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| 4 serious SE of aminoglycosides | ototoxicity, acute renal failure, NM blockade, repiratory paralysis
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| Spectinomycin: MOA and use | inhibits translocation, Alternative gonorrhea therapy
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| You can’t use these 2 drugs with active Neisseria infections | rifampin and rifabutin
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| Abx used in malaria prophylaxis | doxycycline
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| Abx class that is actively transported into bacterial cells | tetracyclines
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| The only tetracycline that can be used in renal patients | doxycycline
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| Use tetracyclines to treat these 7 bugs | C. acnes, H flu, vibrio cholera, spirochetes, mycoplasma pneumonia, and rickerrsial species
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| Class that causes bulging fontanelle, discoloration and stunting of bone growth, hepatotoxicity, and pseudotumor cerebri | tetracyclines
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| Use tigecycline for | skin infections and complicated abdominal infx
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| 4 Keto-Macro-lides | Azithromycin, Clarithromyciin, Erythromycin, Telithromycin
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| Clarithromycin has increased activity against | H. flu
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| Azithromycin has increased activity against | H.flu and Moraxella cattarrhalis
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| Class that can cause ototoxicity, acute cholestatic hepatitis | macro/ketolides
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| SE specific to telithromycin | fulminant hepatic necrosis
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| Macrolides effect digoxin how? | increases oral absorption
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| 3 SE of chloramphenicol | hemolytic anemia w/ G6PD def., gray baby, aplastic anemia
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| Clindamycin has good coverage of what | anaerobes
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| 3 SE of clindamycin | C. diff, increased LFTs and jaundice
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| Used to treat VRE, and staph and strep | daldopristin/quinupristine
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| daldopristin/quinupristine should not be used with what 2 drugs | SSRIs= serotonin syndrome; pimozide=torsades
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| Use for diabetic foot Infx, VRE, MRSA, S. pneumo, nosocomial pneumonia | linezolid
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| Can cause myelosupression, peripheral neuropathy, and optic neuropathy | linezolid
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