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Pharm 32 Abx DNA
LECOM Pharm 32 Abx DNA translation transcription
| Question | Answer |
|---|---|
| Mnemonic for 50s vs 30s inhibitors and what they stand for | CLEan TAG: Clinda/Chloramphenicol, Linezolid, Erythro, Tetra/Tigecycline, AG= aminoglycosides |
| Ending and MOA of quinolones | -floxacin; Topoisomerase II inhibitors |
| What do you used quinolones to treat | gram negatives |
| 6 SE of Quinalones | cartilage/tendon rupture, peripheral neuropathy, increased ICP, seizure, sever hypersensitivity reactions |
| MOA of rifampin and rifabutiin | bind bacterial DNA dependant RNA polymerase |
| Used for meningitis prophylaxis | rifampin |
| 2 SE of rifampin.rifabutin | thrombocytopenia and hepatotoxicity |
| Group of Abx that is bactericidal causing mRNA misreads | Aminoglycosides |
| Use AG to treat? | serious gram negative bugs |
| 4 serious SE of aminoglycosides | ototoxicity, acute renal failure, NM blockade, repiratory paralysis |
| Spectinomycin: MOA and use | inhibits translocation, Alternative gonorrhea therapy |
| You can’t use these 2 drugs with active Neisseria infections | rifampin and rifabutin |
| Abx used in malaria prophylaxis | doxycycline |
| Abx class that is actively transported into bacterial cells | tetracyclines |
| The only tetracycline that can be used in renal patients | doxycycline |
| Use tetracyclines to treat these 7 bugs | C. acnes, H flu, vibrio cholera, spirochetes, mycoplasma pneumonia, and rickerrsial species |
| Class that causes bulging fontanelle, discoloration and stunting of bone growth, hepatotoxicity, and pseudotumor cerebri | tetracyclines |
| Use tigecycline for | skin infections and complicated abdominal infx |
| 4 Keto-Macro-lides | Azithromycin, Clarithromyciin, Erythromycin, Telithromycin |
| Clarithromycin has increased activity against | H. flu |
| Azithromycin has increased activity against | H.flu and Moraxella cattarrhalis |
| Class that can cause ototoxicity, acute cholestatic hepatitis | macro/ketolides |
| SE specific to telithromycin | fulminant hepatic necrosis |
| Macrolides effect digoxin how? | increases oral absorption |
| 3 SE of chloramphenicol | hemolytic anemia w/ G6PD def., gray baby, aplastic anemia |
| Clindamycin has good coverage of what | anaerobes |
| 3 SE of clindamycin | C. diff, increased LFTs and jaundice |
| Used to treat VRE, and staph and strep | daldopristin/quinupristine |
| daldopristin/quinupristine should not be used with what 2 drugs | SSRIs= serotonin syndrome; pimozide=torsades |
| Use for diabetic foot Infx, VRE, MRSA, S. pneumo, nosocomial pneumonia | linezolid |
| Can cause myelosupression, peripheral neuropathy, and optic neuropathy | linezolid |
Created by:
csheck
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