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GI Drugs

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Question
Answer
Drugs for Peptic Ulcer Disease   Tagamet, Pepcid, Zantac, Prilosec, Nexium, Prevacid, Protonix, Carafate, Cyotec  
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H2 Receptor Antagonist - Blocks secretion of gastric acid   Tagamet, Pepcid, Zantac  
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Tagamet   Use cautiously in elderly, may cause confusion. Interferes with coumadin and dilantin  
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Pepcid   Can decrease platelet count (thrombocytopenia)  
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Proton Pump Inhibitors   Prilosec, Nexium, Prevacid, Protonix  
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Prilosec, Nexium, Prevacid, Protonix   Permanently inhibit enzymes that produce gastric acid. Recommended to take for 4-8 weeks, not long term. Increases pH of stomach which increases bacterial growth making an increased risk for pneumonia  
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Carafate   Adheres to opening of ulcer and creates barrier against acid. Does not neutralize acid or decrease secretion. Administer on empty stomach and do not give w/ other meds  
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Cytotec   Used to prevent ulcers from NSAID use. Category X. S/E: Diarrhea, vaginal spotting, stimulates uterine contractions  
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Zofran   Treats nausea, vomiting from radiation, chemo and post surgicals  
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Scopalamine   Used for motion sickness. S/E: (anticholinergic) dry mouth, blurred vision, urinary retention, constipation  
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Compazine   Increased prolonged QT which can lead to dysrhythmias. Sedative effect. S/E: (anticholinergic) dry mouth, blurred vision, urinary retention, constipation  
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Inapsine & Phenergan   Used with kids. Has a sedative effect  
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Reglan   Works in brain to block vomiting, increases peristalsis (moves bowel)  
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Imodium   Anti-diarrheal. Suppresses bowel motility. Decreases fluids in bowel lumen. If take to much get constipated  
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Pepto Bismol   Anti-diarrheal S/E: Can cause blackened stools and tongue.  
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Zellnorm   Used for irritable bowel syndrome. Do not use if cardiovascular risks. Increased GI motility & secretions. Decreased bloating, constipation and abdominal pain.  
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Laxatives   Citrucel, Colace, Golytely, Senakot, Dulcolax  
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Citrucel   Laxative that produces soft formed stool in 1-3 days. Absorbs water (draws H2O) into bowel. Softens and enlarges fecal mass stimulating peristalsis  
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Colace   Laxative that facilitates penetration of water and electrolytes into bowel (stool softener). Used for post-op patients  
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Golytely   Laxative: Powder form: Used as osmotic laxative to make you go and go. Used pre-op (colonoscopy). Low dose (1x day) = semi-fluid BM in 6-12 hours. High Dose = liquid stool in 2-6 hours  
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Senakot   Laxative that stimulates peristalsis. See stool in 6-12 hours  
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Dulcolax   Laxative that can be given as suppository. BM in 15-60 minutes  
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Antacids   Taken 1-3 hours after meal & at bedtime. Bases/alkaline compounds that neutralize stomach acid  
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Milk of Magnesia   Magnesium based. Can cause diarrhea. Do not give if obstruction or appendicitis. Avoid w/ renal patients  
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Mylanta, Maalox, Gaviscon   Have aluminum and magnesium (antacids)  
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Magnesium based   causes diarrhea  
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Aluminum based   causes constipation  
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Drugs for Inflammatory Bowel Diseases   Sulfasalazine, Asacol, Prednisone, Imuran, Remicade  
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Sulfasalazine   First choice drug for IBD, decreases inflammation in bowel. S/E: yellow/orange discoloration of skin/urine, photosensitivity, nausea, fever, rash. Avoid w/ sulfa allergy  
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Asacol   Used for IBD, decreases inflammation. S/E: headache and GI upset  
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Prednisone   Used for IBD. Gets them into remission  
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Imuran   Used for IBD. Gets them into remission, only used for patients who do not respond to other therapy. Not a first choice drug  
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Remicade   Inhibits tubonecrosis factor. Given IV. Give initial infusion again at 2, 6, 8 weeks then q8 weeks. Watch for infection, TB opportunis. Infusion reaction (fever, chills, hives, chest pain, dyspnea). Not always covered by insurance, very expensive  
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Hepatitis (viral)   Alpha-interpheron, Epivir, Hepsera, Ribavirin  
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Alpha-interpheron   Blocks viral entry into cells and synthesis of viral proteins, given subcut. S/E: arthrodial (joint) pain, fatigue, depression, insomnia, & injection site reactions  
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Epivir   Used for Hep B. Given po for 1 year. Inhibits viral DNA synthesis. Use caution in renal patients. reserved for pregnant women or immune compromised  
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Hepsera   Used with Epivir for resistant Hep B. Given po for 1 year. Nephrotoxic  
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Rebetol   Used for Hep C given 2x week. S/E: Anemia, anorexia. Avoid in pregnancy. Treat yourself and your partner  
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Cirrhosis   Vitamin K, Lactulose, Inderal, Aldactone, Questran  
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Vitamin K   Given subcut or IV. Stimulates liver to increase clotting factors  
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Lactulose   Decreases ammonia levels which is secreted in feces. Still give if patient has diarrhea  
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Inderal   Beta blocker. Used for portal HTN and for patients with esophagogastritis to decrease bleeding.  
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Aldactone   Potassium sparing diuretic. Blocks action of aldosterone  
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Questran   Binds to bile salts. Decreases cholesterol and irritation of gastric mucosa. Administered before or w/ meals  
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Pancreatic Enzymes   Pancreatin & Pancrealipase  
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Pancreatin & Pancrealipase   Replacement enzymes for pancreas. Enteric coated to protect medicine. Taken w/ every meal and snack  
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Bentyl   Decreases pain from pancreatitis  
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Meridia   Appetite suppression. used short term <12 weeks. S/E: Increased BP and heart rate, dry mouth and insomnia  
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Xenical   Blocks fat breakdown and absorption in intestines. Undigested fat is excreted in feces. S/E: Leakage of stool, flatulance, diarrhea, and bloating  
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Pitressin   Vasopressor that can be used like epinephrine to vasoconstrict around an ulcer to slow bleeding  
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Sandostatin   an IV med for GI bleed that decreases acid and irritability in the stomach  
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Actigall   Breaks apart gallstones clogging duct  
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Neomyocin   Antibiotic, Decreases ammonia producing bacteria in gut. Give po  
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Cyclosporine   Given to transplant patients to bring down chance of rejecting organ  
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