Chapter 51 anticoagulants, antiplatelets, fibrinolytics
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| MOA of antithrombin activators - unfractioned | unfractioned Heparin activates antithrombin to inhibit Xa and thrombin
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| MOA of antithrombin activators - LMW, pentasaccharide | this class activates antithrombin to inhibit Xa only
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| Name 3 LMW heparins | enoxaparin, dalteparin, tinzaparin
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| LMW heparin #1 | enoxaparin
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| LMW heparin #2 | dalteparin
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| LMW heparin #3 | tinzaparin
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| Name 1 pentasaccharide heparin Xa inhibitor | fondaparinux
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| What class of drug is warfarin (oral) | Vitamin K antagonist that inhibits liver synthesis of factors 2 (prothrombin),7,9 and 10 without effecting preformed factors
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| What are the 2 major ADRs of heparin | hemorrhage, heparin induced thrombocytopenia
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| MOA of heparin induced thrombocytopenia | immune response causes increased tendency for platelet to clot. Must immediately stop all heparin, give a fibrinolytic and admin a direct thrombin inhibitor (antithrombotic) in heparin's place as
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| Name 4 direct thrombin inhibitors/antithrombotics | bivalirudin, lepirudin, desirudin, argatroban
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| antithrombotic #1 | bivalirudin
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| antithrombotic #2 | lepirudin
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| antithrombotic #3 | desirudin
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| antithrombotic #4 | argatroban
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| All atithrobmotics are given IV except this SQ admin | desirudin
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| What new drug is also a throbmin inhibitor | dabigatran (no antidote)
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| what new drug is a thrombin inhibitor, factor Xa | rivaroxaban (no antidote)
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| What drug is Pregnancy X with many drug interactions | warfarin
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| What are the two classes of oral antiplatelet thromboxane inhibitors | irreversible - ASA, reversible NSAIDs
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| What are the the oral anti-platelet drugs in the ADP inhibitor class (4) | clopidogrel, ticagrelor, ticlopidine, prasugrel
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| ADP inhibitor #1 | clopidogrel
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| ADP inhibitor #2 | ticagrelor
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| ADP inhibitor #3 | ticlopidine
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| ADP inhibitor #4 | prasugrel
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| What class of antiplatelet drugs have parenteral admin | Platelet glycoprotein IIb/IIIa antagonists
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| Name 3 pltGp IIb/IIIa antagonists, all IV admin | abciximab, eptifibatide, tirofiban
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| pltGP antagonist #1 | abciximab
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| pltGP antagonist #2 | eptifibatide
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| pltGP antagonist #3 | tirofiban
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| What is MOA of thrombolytic drugs | activate plasmin to digest fibrin clot
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| Name 3 thrombolytic drugs | ateplase, reteplase, tenecteplase
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| thrombolytic drug #1, 2 IV dose infusions | ateplase
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| thrombolytic drug #2, 2 IV bolus | reteplase
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| thrombolytic drug #3, single IV dose | tenecteplase
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