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NURS 572A Ch 51

Chapter 51 anticoagulants, antiplatelets, fibrinolytics

MOA of antithrombin activators - unfractioned unfractioned Heparin activates antithrombin to inhibit Xa and thrombin
MOA of antithrombin activators - LMW, pentasaccharide this class activates antithrombin to inhibit Xa only
Name 3 LMW heparins enoxaparin, dalteparin, tinzaparin
LMW heparin #1 enoxaparin
LMW heparin #2 dalteparin
LMW heparin #3 tinzaparin
Name 1 pentasaccharide heparin Xa inhibitor fondaparinux
What class of drug is warfarin (oral) Vitamin K antagonist that inhibits liver synthesis of factors 2 (prothrombin),7,9 and 10 without effecting preformed factors
What are the 2 major ADRs of heparin hemorrhage, heparin induced thrombocytopenia
MOA of heparin induced thrombocytopenia immune response causes increased tendency for platelet to clot. Must immediately stop all heparin, give a fibrinolytic and admin a direct thrombin inhibitor (antithrombotic) in heparin's place as
Name 4 direct thrombin inhibitors/antithrombotics bivalirudin, lepirudin, desirudin, argatroban
antithrombotic #1 bivalirudin
antithrombotic #2 lepirudin
antithrombotic #3 desirudin
antithrombotic #4 argatroban
All atithrobmotics are given IV except this SQ admin desirudin
What new drug is also a throbmin inhibitor dabigatran (no antidote)
what new drug is a thrombin inhibitor, factor Xa rivaroxaban (no antidote)
What drug is Pregnancy X with many drug interactions warfarin
What are the two classes of oral antiplatelet thromboxane inhibitors irreversible - ASA, reversible NSAIDs
What are the the oral anti-platelet drugs in the ADP inhibitor class (4) clopidogrel, ticagrelor, ticlopidine, prasugrel
ADP inhibitor #1 clopidogrel
ADP inhibitor #2 ticagrelor
ADP inhibitor #3 ticlopidine
ADP inhibitor #4 prasugrel
What class of antiplatelet drugs have parenteral admin Platelet glycoprotein IIb/IIIa antagonists
Name 3 pltGp IIb/IIIa antagonists, all IV admin abciximab, eptifibatide, tirofiban
pltGP antagonist #1 abciximab
pltGP antagonist #2 eptifibatide
pltGP antagonist #3 tirofiban
What is MOA of thrombolytic drugs activate plasmin to digest fibrin clot
Name 3 thrombolytic drugs ateplase, reteplase, tenecteplase
thrombolytic drug #1, 2 IV dose infusions ateplase
thrombolytic drug #2, 2 IV bolus reteplase
thrombolytic drug #3, single IV dose tenecteplase
Created by: lorrelaws