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NURS 572A Ch 51
Chapter 51 anticoagulants, antiplatelets, fibrinolytics
| Question | Answer |
|---|---|
| MOA of antithrombin activators - unfractioned | unfractioned Heparin activates antithrombin to inhibit Xa and thrombin |
| MOA of antithrombin activators - LMW, pentasaccharide | this class activates antithrombin to inhibit Xa only |
| Name 3 LMW heparins | enoxaparin, dalteparin, tinzaparin |
| LMW heparin #1 | enoxaparin |
| LMW heparin #2 | dalteparin |
| LMW heparin #3 | tinzaparin |
| Name 1 pentasaccharide heparin Xa inhibitor | fondaparinux |
| What class of drug is warfarin (oral) | Vitamin K antagonist that inhibits liver synthesis of factors 2 (prothrombin),7,9 and 10 without effecting preformed factors |
| What are the 2 major ADRs of heparin | hemorrhage, heparin induced thrombocytopenia |
| MOA of heparin induced thrombocytopenia | immune response causes increased tendency for platelet to clot. Must immediately stop all heparin, give a fibrinolytic and admin a direct thrombin inhibitor (antithrombotic) in heparin's place as |
| Name 4 direct thrombin inhibitors/antithrombotics | bivalirudin, lepirudin, desirudin, argatroban |
| antithrombotic #1 | bivalirudin |
| antithrombotic #2 | lepirudin |
| antithrombotic #3 | desirudin |
| antithrombotic #4 | argatroban |
| All atithrobmotics are given IV except this SQ admin | desirudin |
| What new drug is also a throbmin inhibitor | dabigatran (no antidote) |
| what new drug is a thrombin inhibitor, factor Xa | rivaroxaban (no antidote) |
| What drug is Pregnancy X with many drug interactions | warfarin |
| What are the two classes of oral antiplatelet thromboxane inhibitors | irreversible - ASA, reversible NSAIDs |
| What are the the oral anti-platelet drugs in the ADP inhibitor class (4) | clopidogrel, ticagrelor, ticlopidine, prasugrel |
| ADP inhibitor #1 | clopidogrel |
| ADP inhibitor #2 | ticagrelor |
| ADP inhibitor #3 | ticlopidine |
| ADP inhibitor #4 | prasugrel |
| What class of antiplatelet drugs have parenteral admin | Platelet glycoprotein IIb/IIIa antagonists |
| Name 3 pltGp IIb/IIIa antagonists, all IV admin | abciximab, eptifibatide, tirofiban |
| pltGP antagonist #1 | abciximab |
| pltGP antagonist #2 | eptifibatide |
| pltGP antagonist #3 | tirofiban |
| What is MOA of thrombolytic drugs | activate plasmin to digest fibrin clot |
| Name 3 thrombolytic drugs | ateplase, reteplase, tenecteplase |
| thrombolytic drug #1, 2 IV dose infusions | ateplase |
| thrombolytic drug #2, 2 IV bolus | reteplase |
| thrombolytic drug #3, single IV dose | tenecteplase |
Created by:
lorrelaws
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