hematopoeitic growth factors
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| hematopoietic growth factors treat for | RBC, WBC
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| thrombopoietic growth factors treat for | platelets
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| how must all hematopoietic growth factors be admin | parentarally
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| epoetin-alpha MOA | recomb DNA --> RBC production. Need essential Fe, Folic Acit, Vit B12
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| indications for epoetin-alpha | chronic renal failure, HIV +, chemorx pts, anemic pts facing surgery
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| Epoetin-alpha ADRs | HTN (increased Hgb) --> MI, CVA, HF
very rare autoimmune red cell aplasia
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| epoetin-alph monitoring | Hgb should be 10-12 g/dL, monitor bp q 4. May require anti-HTN med
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| Darbepoetin-alpha | modified epoetin for double the half-life of 48 hours
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| Methoxypolyethylene glcol epoetin-beta | modified epoetin lasting much longer, q2 week admin
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| Filgrastim-G-CSF full name | filgrastim granulocyte colony stimulating factor
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| filgrastim-G-CSF indications | to elevate neutrophil counts in cancer pts EXCEPT myeloid cancers
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| Filgrastim - G - CSF ADRs | bone pain, leukocytosis (increases to 100,000)
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| filgrasti - G - CSF monitoring | monitor CBC, temp, infection, bone pain
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| Pegfilgrastim | peglated with polyethylene glycol to increase half life, otherwise same as filgrastim
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| sargramostin GM-CSF full name | granulocyte + macrophage/monocyte colony stimulating factor
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| Sargramostin GM CSF indications | bone marrow transplant pts, to increase neutrophils, macrophages/monocytes
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| sargramostin GM CSF ADRs | diarrhea, weakness, rash, bone pain, leukocytosis and/or thrombocytosis
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| oprelveken IL-11 full name | oprelvekin interleukin-11
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| oprelvekin IL-11 MOA | thrombopoietic growth factor stimulates megakaryocytes and maturation
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| oprelvekin IL-11 indications | for myelosuppresive chemorx to minimize thrombocytopenia, decreasing the need for platelet transfusion
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| oprelvekin IL-11 ADRs #1 | Na/fluid retention --> 15% increase in plasma volume --> peripheral edema --> HF
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| oprelvekin IL-11 ADRs #2 | cardiac dysrthythmias, blurred vision, papilledema, rarely death
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