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Inflammatory and Infectious Disorders of the Nervous System

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Question
Answer
What infections can cause meningitis?   Ear, Nose, and Blood  
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What are the causes of meningitis?   Bacterial, Viral, and Fungal  
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What is Brudzinskis Sign?   Flexion of the neck produces flexion of the hips and knees  
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What is Kertigs Sign?   Inability to extend the leg when the thigh is flexed on the abdomen without extreme pain.  
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What is Opisthotonos?   An extreme hyperextension of the neck and arching of the back.  
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List 5 S/Sx of meningitis:   *Fever *Nuchal rigidity (Neck stiffness) *N/V *Altered LOC *Photophobia *Kernigs sign *Brudzinskis sign *Opisthotonos  
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Antibiotics given for meningitis need to be able to do what?   Cross the blood brain barrier  
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What are hyperosmolar agents?   Agents effective in reducing ICP through 1)Plasma expansion w/decrease in hematocrit and cerebral blood volume 2)draws CSF from brain into circulation  
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The bed of a PT with meningitis must be placed how?   HOB elevated  
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Encephalitis is most often caused by what?   A virus (measles, chicken pox, mumps ect..)  
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When is encephalitis more prevalent?   After flu epidemics  
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What form of encephalitis is a common complication of AIDS?   Cytomegalovirus Encephalitis  
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What S/Sx seperate Meningitis and Encephalitis?   *Visual disturbances *Tremor/ Muscle weakness *Lack of coordination *Spastic/flaccid paralysis *Convulsions  
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What medications are given to control ICP?   *Hyperosmolar agents *Mannitol *Corticosteroids  
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What can be given to reduce the mortality from Herpes Simplex encephalitis from 70%-30%?   Antivirals (Acyclovir is prefered due to fewer side effects)  
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What is Guillian-Barre Syndrome (GBS)?   Widespread inflammation and demyelination of the peripheral nervous system. Antibodies attack the schwann cells which compose the myelin sheath. Uninsulated nerve inflames, interrupting nerve transmission.  
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What are the first symptoms of Guillian-Barre Syndrome (GBS)?   Motor weakness and numbness/tingling  
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Where does the symptoms of GBS start?   Lower extremities, then move upward  
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How does remyelination occur in GBS?   demyelination is self limiting. Remylination occurs in revers, starting at upper extremities and moves downward.  
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When is a craniotomy indicated in a brain abscess?   If the abscess is encapsulated and antimicrobial therapy cant reach it.  
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