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AIDS and the Human Immunodeficiency Virus (HIV)

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Question
Answer
HIV is a member of what family of viruses?   Lentivirus  
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What is the name given to HIV at its discovery in 1984?   Human T-cell Lymphotropic Virus Type lll (HTLVlll).  
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Where is HIV-1 prevalent?   Found worldwide but more prevalent in the US and Europe  
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Where is HIV-2 prevalent?   prevalent in Western Africa and countries with historical and commercial ties to that region  
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HIV is an obligate virus. What is an obligate virus?   A virus that needs a living host to survive.  
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How many copies of HIV are generated and cleared daily during the acute infection period?   10 billion  
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How many CD4 lymphocytes are produced and destroyed daily during the initial phase of the HIV infection?   Nearly 2 billion  
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What is seroconversion?   a person is said to have seroconverted when there is development of a detectable level of HIV antibodies found in the blood  
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When does seroconversion take place?   1 to 12 weeks after exposure  
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What are the initial symptoms of HIV?   mononucleosis-like or flu-like symptoms, or mild to asymptomatic  
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What is the median time between HIV infection and the development of end-stage of HIV disease, or AIDS, in an untreated individual?   10 - 14 years  
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What is the CDC definition for AIDS?   All HIV infected persons with CD4 T-lymphocyte counts <200 cells/mm3 or a CD4 percentage of <14 %  
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Does HIV cross the placental barrier? Breast milk?   No, Yes  
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What are the four most common modes of HIV transmision?   *Unprotected anal or vaginal intercourse *Contaminated injecting drug equipment *Transmission from mother to child (vertical transmission) *Occupational exposure  
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What is the gold standard screening test for HIV that is rapid and sensitive?   ELISA or enzyme immunoassay (EIA)  
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What is done if the enzyme immunoassay (EIA) test is positive?   A second, very specific test will be done using the Western Blot.  
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What test CONFIRMS the presence of HIV?   Western Blot  
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What test is used to measure the progression of the HIV infection?   'viral load' test that measures the number of viral particles in the blood  
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How long does it take after exposure to detect HIV antibodies?   Normally 1-12 weeks (95%  
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What are the barriers to HIV prevention?   *Denial; “It won’t happen to me.” *Stereotyping; “It’s only a homosexual disease.” *Fear; potential for social isolation and stigmas. *Cultural and community attitudes  
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What is a Retrovirus?   a virus that carries its genetic material in RNA rather than DNA, and it replicates by converting RNA into DNA using the enzyme reverse transcriptase  
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What is an Enzyme-linked Immunoabsorbent Assay (ELISA or EIA) test?   a rapid enzyme immunochemical assay method to detect certain bacterial antigens and antibodies; a screening test with high sensitivity  
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