Androgens, ED, BPH
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each of the black spaces below before clicking
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| function of testosterone - both genders | anabolic and erythropoetic
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| 2 classifications of testosterone | 1- testosterone and testosterone esters
2 - 17-alpha-alkylated testosterone
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| 3 examples of testosterone/esters | *testosterone
*testosterone cypionate
*testosterone ethanthate
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| 3 examples of 17-alpha-alkylated testosterone | *fluoxymesterone
*methyl testosterone
*oxandrolone
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| which class is given po and has ADR for hepatotoxicity | 17-alpha-alkylated testosterone
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| What are routes for testosterone | IM, transdermal (patch, gel), implantable pellets, buccal
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| Which class is given po | 17-alkylated testosterone (fluoxymesterone, methyltestosterone)
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| Two mechanisms by which ED occurs | 1 - cGMP nec for sm relax so blood can fill penis . . .degraded by PDE5
2- vasodilate arterial sm musc relax for increased blood flow
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| Two class of drugs to treat ED | 1. vasodilator agents
2. PDE5 inhibitors
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| 2 other drugs to treat ED | 1- apopmorphine
2- yohimbine
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| 4 PDE5 inhibitors | 1- sildenafil
2- vardenafil
3- tadalafil
4- avanafil
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| Which 2 PDE5 inhibitors have a 4 hour duration | sidenafil and vardenafil
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| Which PDE5 inhibitor has up to 36 hour duration | tadalafil
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| Which PDE5 inhibitor is least metabolized, showing up most in urine | tadalafil
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| who is contraindicated for taking PDE5 inhibitors | anyone taking nitrates (alpha-blockers, anti-HTN, cardiac drugs) bc they all have combined effect to lower bp to lethal levels
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| Name 2 ED vasodilator agents | 1. papaverine/phentolamine
2. alprostadil
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| what is MOA of ED vasodilator agents | 1. inc arterial blood flow (sm muscle relax)
2. alpha blocker --> vasodil
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| What ED drug is penile injection route | papaverine/phentolamine
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| What ED drug is admin either penile injection or transurethral suppository | alprostadil
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| What ED drug class is po admin | PDE5 inhibitors (sildenafil, vardenafil, tadalafil)
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| What is basic mechanism of BHP benign prostatic hyperplasia | 1 - increase sm muscle cells--> dynamic obstruction urethra
2 - inc epi cells --> gland size
-->mechanical pressure on urethra
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| What are two classes of drugs that treat BHP | 1- Alpha-1 adrenergic blockers
2- 5-alpha-reductase inhibitors
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| What is MOA of the BHP alpha-1 blockers | relaxes sm musc t/o prostate
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| What is MOA of 5-alpha-reductase inhibitors | decreased prostate size
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| 6 drugs in alpha-1 blockers (BHP) | 1- silodosin
2 - terazosin
3- doxazosin
4- tamsulosin
5- alfuzosin
6 - prazosin
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| BHP alpha 1 blocker | silodosin
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| BHP alpha 1 blocker | terazosin
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| BHP alpha 1 blocker | doxazosin
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| BHP alpha 1 blocker | tamsulosin
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| BHP alpha 1 blocker | alfuzosin
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| BHP alpha 1 blocker | prazosin
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| BHP 5-alpha reductase inhibitor | finasteride
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| BHP 5-alpha reductase inhibitor | dutasteride
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| ED vasodilator | papaverine/phentolamine
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| ED vasodilator | alprostadil
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| ED PDE5 inhibitor | sildenafil
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| ED PDE5 inhibitor | vardenafil
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| ED PDE5 inhibitor | tadalafil
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| Which BHP 5-alpha reductase inhibitor is teratogenic | dutasteride
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| Which alpha-1 blocker contraindicated for severe liver impairment | silodosin
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