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NURS 572A 64,65

Androgens, ED, BPH

function of testosterone - both genders anabolic and erythropoetic
2 classifications of testosterone 1- testosterone and testosterone esters 2 - 17-alpha-alkylated testosterone
3 examples of testosterone/esters *testosterone *testosterone cypionate *testosterone ethanthate
3 examples of 17-alpha-alkylated testosterone *fluoxymesterone *methyl testosterone *oxandrolone
which class is given po and has ADR for hepatotoxicity 17-alpha-alkylated testosterone
What are routes for testosterone IM, transdermal (patch, gel), implantable pellets, buccal
Which class is given po 17-alkylated testosterone (fluoxymesterone, methyltestosterone)
Two mechanisms by which ED occurs 1 - cGMP nec for sm relax so blood can fill penis . . .degraded by PDE5 2- vasodilate arterial sm musc relax for increased blood flow
Two class of drugs to treat ED 1. vasodilator agents 2. PDE5 inhibitors
2 other drugs to treat ED 1- apopmorphine 2- yohimbine
4 PDE5 inhibitors 1- sildenafil 2- vardenafil 3- tadalafil 4- avanafil
Which 2 PDE5 inhibitors have a 4 hour duration sidenafil and vardenafil
Which PDE5 inhibitor has up to 36 hour duration tadalafil
Which PDE5 inhibitor is least metabolized, showing up most in urine tadalafil
who is contraindicated for taking PDE5 inhibitors anyone taking nitrates (alpha-blockers, anti-HTN, cardiac drugs) bc they all have combined effect to lower bp to lethal levels
Name 2 ED vasodilator agents 1. papaverine/phentolamine 2. alprostadil
what is MOA of ED vasodilator agents 1. inc arterial blood flow (sm muscle relax) 2. alpha blocker --> vasodil
What ED drug is penile injection route papaverine/phentolamine
What ED drug is admin either penile injection or transurethral suppository alprostadil
What ED drug class is po admin PDE5 inhibitors (sildenafil, vardenafil, tadalafil)
What is basic mechanism of BHP benign prostatic hyperplasia 1 - increase sm muscle cells--> dynamic obstruction urethra 2 - inc epi cells --> gland size -->mechanical pressure on urethra
What are two classes of drugs that treat BHP 1- Alpha-1 adrenergic blockers 2- 5-alpha-reductase inhibitors
What is MOA of the BHP alpha-1 blockers relaxes sm musc t/o prostate
What is MOA of 5-alpha-reductase inhibitors decreased prostate size
6 drugs in alpha-1 blockers (BHP) 1- silodosin 2 - terazosin 3- doxazosin 4- tamsulosin 5- alfuzosin 6 - prazosin
BHP alpha 1 blocker silodosin
BHP alpha 1 blocker terazosin
BHP alpha 1 blocker doxazosin
BHP alpha 1 blocker tamsulosin
BHP alpha 1 blocker alfuzosin
BHP alpha 1 blocker prazosin
BHP 5-alpha reductase inhibitor finasteride
BHP 5-alpha reductase inhibitor dutasteride
ED vasodilator papaverine/phentolamine
ED vasodilator alprostadil
ED PDE5 inhibitor sildenafil
ED PDE5 inhibitor vardenafil
ED PDE5 inhibitor tadalafil
Which BHP 5-alpha reductase inhibitor is teratogenic dutasteride
Which alpha-1 blocker contraindicated for severe liver impairment silodosin
Created by: lorrelaws