click below
click below
Normal Size Small Size show me how
NURS 572A 64,65
Androgens, ED, BPH
Question | Answer |
---|---|
function of testosterone - both genders | anabolic and erythropoetic |
2 classifications of testosterone | 1- testosterone and testosterone esters 2 - 17-alpha-alkylated testosterone |
3 examples of testosterone/esters | *testosterone *testosterone cypionate *testosterone ethanthate |
3 examples of 17-alpha-alkylated testosterone | *fluoxymesterone *methyl testosterone *oxandrolone |
which class is given po and has ADR for hepatotoxicity | 17-alpha-alkylated testosterone |
What are routes for testosterone | IM, transdermal (patch, gel), implantable pellets, buccal |
Which class is given po | 17-alkylated testosterone (fluoxymesterone, methyltestosterone) |
Two mechanisms by which ED occurs | 1 - cGMP nec for sm relax so blood can fill penis . . .degraded by PDE5 2- vasodilate arterial sm musc relax for increased blood flow |
Two class of drugs to treat ED | 1. vasodilator agents 2. PDE5 inhibitors |
2 other drugs to treat ED | 1- apopmorphine 2- yohimbine |
4 PDE5 inhibitors | 1- sildenafil 2- vardenafil 3- tadalafil 4- avanafil |
Which 2 PDE5 inhibitors have a 4 hour duration | sidenafil and vardenafil |
Which PDE5 inhibitor has up to 36 hour duration | tadalafil |
Which PDE5 inhibitor is least metabolized, showing up most in urine | tadalafil |
who is contraindicated for taking PDE5 inhibitors | anyone taking nitrates (alpha-blockers, anti-HTN, cardiac drugs) bc they all have combined effect to lower bp to lethal levels |
Name 2 ED vasodilator agents | 1. papaverine/phentolamine 2. alprostadil |
what is MOA of ED vasodilator agents | 1. inc arterial blood flow (sm muscle relax) 2. alpha blocker --> vasodil |
What ED drug is penile injection route | papaverine/phentolamine |
What ED drug is admin either penile injection or transurethral suppository | alprostadil |
What ED drug class is po admin | PDE5 inhibitors (sildenafil, vardenafil, tadalafil) |
What is basic mechanism of BHP benign prostatic hyperplasia | 1 - increase sm muscle cells--> dynamic obstruction urethra 2 - inc epi cells --> gland size -->mechanical pressure on urethra |
What are two classes of drugs that treat BHP | 1- Alpha-1 adrenergic blockers 2- 5-alpha-reductase inhibitors |
What is MOA of the BHP alpha-1 blockers | relaxes sm musc t/o prostate |
What is MOA of 5-alpha-reductase inhibitors | decreased prostate size |
6 drugs in alpha-1 blockers (BHP) | 1- silodosin 2 - terazosin 3- doxazosin 4- tamsulosin 5- alfuzosin 6 - prazosin |
BHP alpha 1 blocker | silodosin |
BHP alpha 1 blocker | terazosin |
BHP alpha 1 blocker | doxazosin |
BHP alpha 1 blocker | tamsulosin |
BHP alpha 1 blocker | alfuzosin |
BHP alpha 1 blocker | prazosin |
BHP 5-alpha reductase inhibitor | finasteride |
BHP 5-alpha reductase inhibitor | dutasteride |
ED vasodilator | papaverine/phentolamine |
ED vasodilator | alprostadil |
ED PDE5 inhibitor | sildenafil |
ED PDE5 inhibitor | vardenafil |
ED PDE5 inhibitor | tadalafil |
Which BHP 5-alpha reductase inhibitor is teratogenic | dutasteride |
Which alpha-1 blocker contraindicated for severe liver impairment | silodosin |