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grcc bi240 transplants

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Question
Answer
allograft   between same species but differ genetically  
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isograft   between genetically identical bodies  
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autograft   from one owns body part  
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xenograft   from one species to another (from pig to human)  
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Transplant rejection happens due to   Human Leukocytic antigens in foreign tissue - rejecting it and then destroy  
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There are 2 classification of glycoprotiens (AKA HLA or MHA)   Class 1 & II  
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CLASS I Glycoproteins   found on surface of cells and recognized by cytotoxic T cells  
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Class 1 glycoprotein is on surface of the cell and recognized by cytotoxic T cells prevents   human to human tranplant from being successful.  
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Class II Glycoproteins   found on surface of B cells, T cells and macrophages  
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Class II is on the surface of B cells, T cells, and macrophages and prevents successful tranplant because   it is recognized by T- helper cells.  
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T help cells facilitates   immune response by interupting antibodies produced by B cells, regulates cells.  
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Transplant reject is a complex process that involves which type of cell?   Type IV hypersensitive cell mediated reaction.  
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Type IV hypersensitive cell mediated reaction   attack and destroy cellular targets  
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How does Type IV cells attack and destroy their target?   Cell mediated immunity develops wehn t cells recognize antigens on the surface of target cells & destroy.  
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T cells differentiate into Cytotoxic T cells producing helper T cells which in turn produce cytokines   this activates macrophages which attach to targets releasing enzymes and inducing aptopsis.  
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Host rejects grafts   Host vs graft (HVGD)  
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Grafts rejects Host   Grafts Vs. Host disease (GVHD)  
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Hyper-acute rejection   Occurs immediately.  
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acute rejection   after weeks  
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chronic rejection   after months or years.  
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immunosuppression   drugs are given to decrease immune response and prevent rejection.  
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Prednisone messes   with Blood sugar, increase risk for infection and developing osteoporosis  
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People with transplant risks increase from   opportunistic infections microorganisms that are usually harmless in a healthy person.  
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If transplant person is diabetic increase risk of rejecting kidney transplant due to   vascular problems  
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Patients taking cyclosporine are at risk for developing   gingival hyperplasia  
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Transplant people have increase risk for developing certain cancers   lymphoma, skin, lip and kaposis sarcoma  
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Created by: Wends1984
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