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bi 240 transplants
grcc bi240 transplants
| Question | Answer |
|---|---|
| allograft | between same species but differ genetically |
| isograft | between genetically identical bodies |
| autograft | from one owns body part |
| xenograft | from one species to another (from pig to human) |
| Transplant rejection happens due to | Human Leukocytic antigens in foreign tissue - rejecting it and then destroy |
| There are 2 classification of glycoprotiens (AKA HLA or MHA) | Class 1 & II |
| CLASS I Glycoproteins | found on surface of cells and recognized by cytotoxic T cells |
| Class 1 glycoprotein is on surface of the cell and recognized by cytotoxic T cells prevents | human to human tranplant from being successful. |
| Class II Glycoproteins | found on surface of B cells, T cells and macrophages |
| Class II is on the surface of B cells, T cells, and macrophages and prevents successful tranplant because | it is recognized by T- helper cells. |
| T help cells facilitates | immune response by interupting antibodies produced by B cells, regulates cells. |
| Transplant reject is a complex process that involves which type of cell? | Type IV hypersensitive cell mediated reaction. |
| Type IV hypersensitive cell mediated reaction | attack and destroy cellular targets |
| How does Type IV cells attack and destroy their target? | Cell mediated immunity develops wehn t cells recognize antigens on the surface of target cells & destroy. |
| T cells differentiate into Cytotoxic T cells producing helper T cells which in turn produce cytokines | this activates macrophages which attach to targets releasing enzymes and inducing aptopsis. |
| Host rejects grafts | Host vs graft (HVGD) |
| Grafts rejects Host | Grafts Vs. Host disease (GVHD) |
| Hyper-acute rejection | Occurs immediately. |
| acute rejection | after weeks |
| chronic rejection | after months or years. |
| immunosuppression | drugs are given to decrease immune response and prevent rejection. |
| Prednisone messes | with Blood sugar, increase risk for infection and developing osteoporosis |
| People with transplant risks increase from | opportunistic infections microorganisms that are usually harmless in a healthy person. |
| If transplant person is diabetic increase risk of rejecting kidney transplant due to | vascular problems |
| Patients taking cyclosporine are at risk for developing | gingival hyperplasia |
| Transplant people have increase risk for developing certain cancers | lymphoma, skin, lip and kaposis sarcoma |
Created by:
Wends1984
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