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bi 240 transplants

grcc bi240 transplants

allograft between same species but differ genetically
isograft between genetically identical bodies
autograft from one owns body part
xenograft from one species to another (from pig to human)
Transplant rejection happens due to Human Leukocytic antigens in foreign tissue - rejecting it and then destroy
There are 2 classification of glycoprotiens (AKA HLA or MHA) Class 1 & II
CLASS I Glycoproteins found on surface of cells and recognized by cytotoxic T cells
Class 1 glycoprotein is on surface of the cell and recognized by cytotoxic T cells prevents human to human tranplant from being successful.
Class II Glycoproteins found on surface of B cells, T cells and macrophages
Class II is on the surface of B cells, T cells, and macrophages and prevents successful tranplant because it is recognized by T- helper cells.
T help cells facilitates immune response by interupting antibodies produced by B cells, regulates cells.
Transplant reject is a complex process that involves which type of cell? Type IV hypersensitive cell mediated reaction.
Type IV hypersensitive cell mediated reaction attack and destroy cellular targets
How does Type IV cells attack and destroy their target? Cell mediated immunity develops wehn t cells recognize antigens on the surface of target cells & destroy.
T cells differentiate into Cytotoxic T cells producing helper T cells which in turn produce cytokines this activates macrophages which attach to targets releasing enzymes and inducing aptopsis.
Host rejects grafts Host vs graft (HVGD)
Grafts rejects Host Grafts Vs. Host disease (GVHD)
Hyper-acute rejection Occurs immediately.
acute rejection after weeks
chronic rejection after months or years.
immunosuppression drugs are given to decrease immune response and prevent rejection.
Prednisone messes with Blood sugar, increase risk for infection and developing osteoporosis
People with transplant risks increase from opportunistic infections microorganisms that are usually harmless in a healthy person.
If transplant person is diabetic increase risk of rejecting kidney transplant due to vascular problems
Patients taking cyclosporine are at risk for developing gingival hyperplasia
Transplant people have increase risk for developing certain cancers lymphoma, skin, lip and kaposis sarcoma
Created by: Wends1984