grcc bi240 complement system & chemical mediators
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| complement system | Helps body recognize foreign and take action to remove it.
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| Complement system activated | during an immune reaction with IgG or IgM
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| Complement is made up of a group of | inactive proteins circulating in blood sequence of events (like dominoes)
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| The complement system leads to a sequence of events results in | destruction of antigen
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| The complement system initiates | inflammatory response
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| chemical mediators are involved in | immune reaction and variety of functions
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| Chemical mediator: complement | group of inactive proteins in circulation
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| when complement is activated it stimulates | release of other chemical mediators
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| complement promotes | inflammation, chemotaxis and phagocytosis
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| Chemical mediator: histamine | released from mast cells and basophils (esp with allergic reactions)
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| histamine causes | vasodilation and increased vascular permeability or edema
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| What causes contractions of bronchiolar smooth muscle and pruritis | histamine
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| Kinin cause | vasodilation, increase permeability (edema) and pain.
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| Prostaglandins | group of lipids
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| cause inflammation, vasodilation, and increased permeability and pain | prostaglandins
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| Leukotrienes | group of lipids derived from mast cells and basophils.
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| Causes contraction of bronchiolar smooth muscle | leukotrienes
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| Leuktriene is a chemical mediator | has a role in development of inflammation
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| Cytokines are messengers produced by | macrophages and activated t cells
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| cytokines stimulate | activation & prolifertaion of b and t cells
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| Is the communicator btween cells | cytokines
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| cytokines are involved in | inflammation, fever, and leukocytosis
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| Tumor necrosis factor (TNF) stimulates | fever, chemotaxis and t cells
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| TNF is the mediator in | tissue wasting and septic shock
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| Stimulates necrosis in some tumors | TNF
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| Chemotactic factors | smoke signal that attracts phagocytes to area of inflamation.
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| cytokines | proteins that communicate between cells and regulate tissue growth and development
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