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GRCC BA240 intro to patho

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The study of functional or physiologic changes in the body that result from disease processes   Pathophysiology  
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We need to understand that any loss or change in normal structure, then loss of function   why we need to understand pathophysiology  
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Which factors of pathophysiology helps figure out the disorder   the disorder displays a set of common set of signs and symptoms related to the organs normal structure or function.  
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An example of knowing the pathophysiology as it relates to signs and symptoms of liver disease.   When clotting factors are not produced leads to excess bleeding- liver is unable to excrete bilirubin - yellow color - inflammation- tissue swells/liver capsule swells - pain.  
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pathophysiology is important because   there are new discoveries made in medicine all of the time.  
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to understand how and why disease develops   The importance of pathophysiology  
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What impacts decision making processing?   Pathophysiology helps us with this  
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pathophysiology helps with   ensuring optimal health and better outcomes.  
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What is a deviation from the normal state of health or from a sttae of wellness?   disease  
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Example of disease   Significan changes in the body - homeostasis cannot be maintained  
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What is affected when homeostatis can't be maintained?   BP, body temperataure, fluid balance, etc  
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World Health Organization (WHO) describes this as physical, emotional and social well being   Health and wellness  
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What plays a role in health and well ness?   Life experience, environmental factors  
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Homeostasis   Process that maintains a stable internal environment  
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Negative feedback   Towards set point; deviation from the set point triggers changes in the body to return to the set point  
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example of negative feedback   body temp, BP, blood sugar levels, etc  
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Positive feedback   away from set point; changes cause body to move away from set point  
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example of positive feedback   clott mechanism, lactation  
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What disrupts the maintenance of the optimal steady state of homeostasis?   the disease process  
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What is Stress Response role in the Disease progression?   Response made by body to any stressor  
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stressor   Any physiological or psychological factor that creates significant change in the body  
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Which critical areas of the body increases in general function due to stressors?   Brain, heart, cell metabolism, lungs  
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Stressors trigger brain to increase the function and short term memory to do what?   release endorphins to block pain  
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Stressors trigger heart to beat faster to do what?   Increase circulation  
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Stressors increases cell   metabolism  
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stressors increases lung activity and leads to   increased oxygen levels  
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What happens when stressors are prolonged?   can cause problems with different areas of body.  
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Stressors prolonged effect on GI leads to   Stomatitis, periodonitis, ulcers, ulcerative collitis, nausea and diarhea  
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Stressors prolonged effect on respiratory   leads to asthma attack  
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Stressors prolonged effect on cardiovascular leads to   htn, angina and chf  
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Stressors prolonged effect on CNS leads to   MS, depression, CVA (stroke)  
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Stressors prolonged effect on muscleskeltal leads to   rheumatoid arthritis (RA)  
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Stressors prolonged effect on GU leads to   acute renal failure  
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Stressors prolonged effect on dermis leads to   herpes simplex, eczema, acne, impaired healing  
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Stressors prolonged effect on other areas of the body lead to   cancer and infection  
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Stressors activate which part of the nervous system?   Central nervous system  
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The central nervous system activates   Hypothalamus  
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hypothalamus   stressor turns on CNS that activates  
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Stress on the SNS signals   adrenal medulla  
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what does the adrenal medulla release   epinephrine and norepinephrine  
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Hypothalamus activates   sns and pituitary  
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adrenal medulla is activated by   SNS  
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what does the adrenal medulla release once the SNS has activated   epi and noriepinephrine  
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They hypothalamus activates the anterior pituitary to release what?   ACTH  
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Anterior Pituitary releases ACTH and activates what?   the adrenal cortex  
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Pituatary   adrenal cortex  
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SNS   adrenal medulla  
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anterior pituitary releases   ACTH to activate the adrenal cortex  
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What does the adrenal cortex released   cortisol and aldosterone  
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Posterior pituitary releases   ADH (anti-diuretic hormone)  
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ADH   retains fluid and increases the workload of the heart  
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anterior pituitary releases ACTH and activates the adrenal cortex that releases   cortisol and glucocorticoids and aldosterone & mineral corticoids  
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Cortisol, glucocorticoids, aldosterone, and mineralcorticoids are actived by   anterior pituitary gland that releases ACTH  
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Norepinephrine effects   vasoconstriction that causes skin pallor, decrease in GFR and increase of BP  
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Epinephrine effects   vasoconstriction that causes skin pallor, decrease GFR, and increase BP  
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Epinephrine effects vasoconstriction   skin pallor, decrease GFR, and increase BP  
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Epinephrine effects on heart   Increase heart rate and contractility  
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Epinephrine effects on lungs   bronchodilation and increase oxygen (more oxygen to tissues)  
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Epinephrine effects on CNS   Increases alertness and increases muscle tone  
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Epinephrine effects on Metabolic   glycogenolysis, lipolysis, gluconeogenesis  
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Cortisol is also known as   stress hormone  
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Cortisol effects on metabolic   protein catabolism, gluconeogenesis  
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Cortisol effects on metabolic breaks down protien and forms new glucose resulting in what?   Increased blood sugar and low serum amino acids, and delayed wound healing  
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Cortisol stimulates what else?   the CNS  
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cortisol effects on the GI   Increases gastric secretions resulting ulcers  
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cortisol effects on the immune response   decreases allergic, inflammation and immune response results in decrease in lymphocytes and antibody production = increase risk for infection  
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stress response releases aldosterone activates   sodium and water retention resulting increased blood volume and increase BP  
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Sress response releases ADH results   increase water absorption and increased blood volume and increase BP  
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