Immunologically Relevant Molecules
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| show | alternative splicing of mRNA mediated by cytokines and CD40
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| show | IgM
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| show | IgA
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| show | IgG (*G*ift from mother)
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| Ig found on surface of b cells and in serum, function unknown | show 🗑
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| Ig that mediates immunity to worms by activating eosinophils | show 🗑
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| show | IgE
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| Most effective opsonin; neutralizes bacterial toxins and viruses | show 🗑
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| show | IgA
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| Prevents attachment of bacteria and viruses to mucous membranes, but does NOT fix complement | show 🗑
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| show | IgM
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| show | IgM
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| show | IgM
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| show | C1
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| deficiency of this complement component leads to recurrent infections with neisseria | show 🗑
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| show | increased susceptibility to type 3 hypersensitivity reactions
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| Cell surface proteins: T cells (general) | show 🗑
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| show | CD4, CD40L
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| show | CD8
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| show | CD 19, 20, 21 (receptor for EBV); MHC II
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| Cell surface proteins: macrophages | show 🗑
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| Cell surface proteins: NK cells | show 🗑
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| show | MHC I
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| Cell surface proteins: WBC, RBC, and platelets (protect against complement-mediated damage) | show 🗑
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| 4 exposures for which patients are given preformed antibodies (for passive immunity) | show 🗑
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| show | RSV
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| show | All nucleated cells (this excludes adult RBCs)
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| show | Antigen presenting cells
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| show | Macrophages, Dendritic cells, B cells
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| show | Type I
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| MHC specific for extracellular pathogens | show 🗑
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| Characteristics of innate immunity | show 🗑
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| show | Specific; Slow, then rapid; Inducible; Memory; Antibodies; B and T cells
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| show | Alpha: leukocytes, Beta: fibroblasts
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| show | Place uninfected cells in "antiviral state": Alpha & beta induce a 2nd protein which degrades viral (but not host) mRNA thereby inhibiting viral protein synthesis
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| show | 1) alpha & beta interferons inhibit viral protein synth, 2) gamma-interferons incr. MHC I and II expression & antigen presentation in all cells, 3) Activate NK cells to kill virus-infected cells
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| show | Formed in bone marrow, Multilobar nuclei, granules, Early defense against bacteria
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| Cells increased in pyogenic infections | show 🗑
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| Macrophages develop in ___ as ___ | show 🗑
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| show | Release of pharmacologically active substances contained within granules - Allergies
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| Role of Eosinophils | show 🗑
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| NK cells target? | show 🗑
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| 2 types of NK cell receptors | show 🗑
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| The 3 complement pathways are components of which immunities? | show 🗑
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| show | System of proteins that interact to play a role in humoral immunity & inflammation
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| Functions of the complement cascade | show 🗑
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| show | 1. C1 cleaves C4 into C4a and C4b, 2. C1 cleaves C2 into C2a and C2b, 3. C4b binds to pathogen surface , 4. C4b binds C2a, 5. C4bC2a cleaves C3 into C3a and C3b, 6. C3b binds to pathogen surface, 7. C3b cleaves C5 into C5a and C5b, 8. C5b activates MAC
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| Factors B, D and properdin are part of which complement pathway only? | show 🗑
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| show | Gram(-) bacteria and viruses
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| Why are gram(+)safe from MAC? | show 🗑
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| Activation of classic complement pathway? | show 🗑
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| show | molecules on the surface of microbes, especially LPS
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| show | C3b & Ig (G or M)
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| Complement factors involved in viral neutralization | show 🗑
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| show | C3b
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| show | C3a, C5a (allergic response, degranulation of eosinophils)
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| show | C5a
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| show | C5b, C6, C7, C8, C9
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| Associated with C1 and C4 deficiencies | show 🗑
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| show | severe recurrent pyogenic sinus & respiratory tract infections
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| C2 deficiency associated with? | show 🗑
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| show | hereditary angioedema (overactive complement)
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| show | Neisseria bacteremia
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| Deficiency of decay accelerating factor (DAF) | show 🗑
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| show | SLE & other autoimmune diseases
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| anti-dsDNA, anti-Smith | show 🗑
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| anti-IgG | show 🗑
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| HLA-B27 | show 🗑
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| HLA-DR2 | show 🗑
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| show | IL-1
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| Cytokine that stimulates growth of *all* T cells | show 🗑
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| Cytokine that supports growth and differentiation of BM stem cells | show 🗑
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| Cytokine that promotes growth of B cells and enhances class switching of IgE, IgG | show 🗑
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| show | IL-5 (also promotes differentiation of B cells, stimulates production and activation of eosinophils)
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| Cytokine that stimulates activation and production of eosinophils | show 🗑
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| Cytokine that stimulates production of acute phase reactants and immunoglobulins | show 🗑
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| IL that is a MAJOR chemotactic factor for PMNs | show 🗑
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| show | IL-10 (secreted by Th2 cells themselves)
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| Cytokine that activates NK cells and Th1 cells | show 🗑
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| "Anticytokine" that inhibits growth and activity of T cells, counteracts effects of inflammatory cytokines, and stimulates wound healing | show 🗑
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| Cytokine increasing IL-2 receptor synthesis by Th cells, and increases B cell proliferation | show 🗑
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| show | IFNγ (secreted by Th1 cells, stimulates macrophages)
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| Signals required for activation of helper T cells | show 🗑
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| show | 1) endogenously synthesized proteins on MHC I recognized by TCR; 2) IL-2 from Th cell activates cytotoxic cell
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| Cell surface proteins of Helper T cells | show 🗑
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| Cell surface proteins of Cytotoxic T cells | show 🗑
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| show | B7, CD19, CD20, CD40, MHC II
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| Cell surface proteins of Macrophages | show 🗑
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| show | Receptors for MHC I, CD16, CD56
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| Cell surface proteins of all cells except mature RBC's (all nucleated cells) | show 🗑
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Created by:
srebeiro
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