LCC NURS 200 unit 5 ACEI's and ARBs
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| ACE Inhibitors – Prototype | captopril (Capoten)
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| ACE Inhibitors MOA | Prevent production of Angiotension II by blocking ACE
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| ACE Inhibitors Indications | Hypertension, Heart failure, Renal protective effects in patients with diabetes, After MI
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| ACE Inhibitors Adverse Effects | Relatively well tolerated. Fatigue/dizziness, hyperkalemia, dry nonproductive cough.
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| ACE Inhibitors Nursing Implication | First does hypotensive effect may occurs. Monitor blood pressure, fall risk. Administer on an empty stomach.
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| ACE Inhibitors Contraindications/Cautions | Allergies, hyperkalemia, hypotension, Renal insufficiency, Causes birth defects in 2nd and 3rd trimester.
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| ACE Inhibitors Interactions | Caution with Potassium sparing diuretic, NSAIDS antagonize ACE Inhibitors, Monitor closely with other antihypertensives.
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| Angiotension II Receptor Blockers (ARBs) Prototype | losartan (Cozaar, Hyzaar)
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| ARBs MOA | Block the effect of AII by blocking receptors that receive AII.
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| ARB Adverse Effects | Dizziness, GI distress (but can give with food), Headache. Does not cause dry cough, hyperkalemia less likely to occur.
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| ARB Contraindications/Cautions | hypotension, renal insufficiency.
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| ARB Interactions. | Careful with other antihypertensives
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