LCC NURS 200 unit 5 Antilipemics
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Total cholesterol | less than 200 mg/dL
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| LDL | less than 100 mg/dL
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| LDL for diabetics or dx of atherosclerosis or other risk factors | Less than 70
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| HDL | greater than 40 mg/dL
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| Triglycerides | less than 150 mg/dL
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| Women triglycerides | less than 135 mg/dL
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| Bile Acid Sequestrants Prototype | colesevelam (Welchol)
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| Bile Acid Sequestrants MOA | prevent absorption of bile acids from small intestine which are necessary for cholesterol production
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| Bile Acid Sequestrants Adverse effects | GI – constipation, hartburn, nausea, belching, bloating, headache, drowsiness, decreased absorption of fat soluble vitamins.
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| Bile Acid Sequestrants Contraindications | Biliary obstruction, intestinal pathology.
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| Bile Acid Sequestrants Interactions | Do not give at the same time as other meds.
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| HMG-CoA Reductase Inhibitors (Statins) Prototype | atorvastatin (Lipitor)
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| Statin MOA | Inhibits HMG-CoA enzyme, lowers rate of cholesterol production in the liver, stimulates production of LDL receptors in liver.
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| Statin Indications | Hyperlipidemia/Hypercholesterolemia, prevention of CV events.
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| Statin Adverse Effects | mild, transient GI disturbances, myopathy, elevations in liver enzymes or liver dysfunction.
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| Statins Contraindications/Cautions | Liver disease, Pregnancy Category X
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| Statin Interactions | Other lipid lowering drugs, drugs that inhibit CYP enzymes, Grapefruit juice.
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| Statin Nursing Implications | Obtain baseline liver function studies. Take daily dose with evening meal.
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| Nicotinic Acid Prototype | Niacin (Vitamin B3)
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| Nicotinic Acid side effects | Flushing, pruritus, nausea, dizziness/orthostatic hypotension.
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| Cholesterol Absorption Inhibitor Prototype | ezetimibe (Zetia)
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| Cholesterol Absorption Inhibitor MOA | prevents dietary absorption of cholesterol in the small intestine.
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| Cholesterol Absorption Inhibitor Indications | Hyperlipidemia
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| Cholesterol Absorption Inhibitor Adverse Effects | Rare reports of myopathy, hepatic impairment.
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| Cholesterol Absorption Inhibitor Contraindications/Cautions | hepatic impairment.
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| Cholesterol Absorption Inhibitor Interactions | Statins (increased risk of liver damage), Bile Acid Sequestrants (don’t take at the same time).
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