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Unit 5 Antilipemics
LCC NURS 200 unit 5 Antilipemics
| Question | Answer |
|---|---|
| Total cholesterol | less than 200 mg/dL |
| LDL | less than 100 mg/dL |
| LDL for diabetics or dx of atherosclerosis or other risk factors | Less than 70 |
| HDL | greater than 40 mg/dL |
| Triglycerides | less than 150 mg/dL |
| Women triglycerides | less than 135 mg/dL |
| Bile Acid Sequestrants Prototype | colesevelam (Welchol) |
| Bile Acid Sequestrants MOA | prevent absorption of bile acids from small intestine which are necessary for cholesterol production |
| Bile Acid Sequestrants Adverse effects | GI – constipation, hartburn, nausea, belching, bloating, headache, drowsiness, decreased absorption of fat soluble vitamins. |
| Bile Acid Sequestrants Contraindications | Biliary obstruction, intestinal pathology. |
| Bile Acid Sequestrants Interactions | Do not give at the same time as other meds. |
| HMG-CoA Reductase Inhibitors (Statins) Prototype | atorvastatin (Lipitor) |
| Statin MOA | Inhibits HMG-CoA enzyme, lowers rate of cholesterol production in the liver, stimulates production of LDL receptors in liver. |
| Statin Indications | Hyperlipidemia/Hypercholesterolemia, prevention of CV events. |
| Statin Adverse Effects | mild, transient GI disturbances, myopathy, elevations in liver enzymes or liver dysfunction. |
| Statins Contraindications/Cautions | Liver disease, Pregnancy Category X |
| Statin Interactions | Other lipid lowering drugs, drugs that inhibit CYP enzymes, Grapefruit juice. |
| Statin Nursing Implications | Obtain baseline liver function studies. Take daily dose with evening meal. |
| Nicotinic Acid Prototype | Niacin (Vitamin B3) |
| Nicotinic Acid side effects | Flushing, pruritus, nausea, dizziness/orthostatic hypotension. |
| Cholesterol Absorption Inhibitor Prototype | ezetimibe (Zetia) |
| Cholesterol Absorption Inhibitor MOA | prevents dietary absorption of cholesterol in the small intestine. |
| Cholesterol Absorption Inhibitor Indications | Hyperlipidemia |
| Cholesterol Absorption Inhibitor Adverse Effects | Rare reports of myopathy, hepatic impairment. |
| Cholesterol Absorption Inhibitor Contraindications/Cautions | hepatic impairment. |
| Cholesterol Absorption Inhibitor Interactions | Statins (increased risk of liver damage), Bile Acid Sequestrants (don’t take at the same time). |
Created by:
npeters519
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