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Unit 5 Antilipemics

LCC NURS 200 unit 5 Antilipemics

Total cholesterol less than 200 mg/dL
LDL less than 100 mg/dL
LDL for diabetics or dx of atherosclerosis or other risk factors Less than 70
HDL greater than 40 mg/dL
Triglycerides less than 150 mg/dL
Women triglycerides less than 135 mg/dL
Bile Acid Sequestrants Prototype colesevelam (Welchol)
Bile Acid Sequestrants MOA prevent absorption of bile acids from small intestine which are necessary for cholesterol production
Bile Acid Sequestrants Adverse effects GI – constipation, hartburn, nausea, belching, bloating, headache, drowsiness, decreased absorption of fat soluble vitamins.
Bile Acid Sequestrants Contraindications Biliary obstruction, intestinal pathology.
Bile Acid Sequestrants Interactions Do not give at the same time as other meds.
HMG-CoA Reductase Inhibitors (Statins) Prototype atorvastatin (Lipitor)
Statin MOA Inhibits HMG-CoA enzyme, lowers rate of cholesterol production in the liver, stimulates production of LDL receptors in liver.
Statin Indications Hyperlipidemia/Hypercholesterolemia, prevention of CV events.
Statin Adverse Effects mild, transient GI disturbances, myopathy, elevations in liver enzymes or liver dysfunction.
Statins Contraindications/Cautions Liver disease, Pregnancy Category X
Statin Interactions Other lipid lowering drugs, drugs that inhibit CYP enzymes, Grapefruit juice.
Statin Nursing Implications Obtain baseline liver function studies. Take daily dose with evening meal.
Nicotinic Acid Prototype Niacin (Vitamin B3)
Nicotinic Acid side effects Flushing, pruritus, nausea, dizziness/orthostatic hypotension.
Cholesterol Absorption Inhibitor Prototype ezetimibe (Zetia)
Cholesterol Absorption Inhibitor MOA prevents dietary absorption of cholesterol in the small intestine.
Cholesterol Absorption Inhibitor Indications Hyperlipidemia
Cholesterol Absorption Inhibitor Adverse Effects Rare reports of myopathy, hepatic impairment.
Cholesterol Absorption Inhibitor Contraindications/Cautions hepatic impairment.
Cholesterol Absorption Inhibitor Interactions Statins (increased risk of liver damage), Bile Acid Sequestrants (don’t take at the same time).
Created by: npeters519