Pharmacology
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| What are the general adverse effects of COX inhibitors? | Gastric ulceration, bleeding, and renal impairment
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| What dose of aspirin is used prophylactically for CHF? | 81 mg
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| What are some other uses of aspirin other than DVT prevention? | Prevention of Alzheimer's disease and cancer (colorectal)
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| What are first generation NSAIDs used for? | To treat inflammatory disorders (e.g., rheumatoid arthritis)
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| What is a major adverse effect of first generation NSAIDs? | GI ulceration
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| What are S/S of aspirin toxicity? | Tinnitus, sweating, headache, and dizziness; progresses to respiratory depression, hyperthermia, dehydration, and acidosis
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| Why is aspirin contraindicated in pregnancy? | Maternal anemia and post-partum hemorrhage
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| Which COX inhibitor is Reye's syndrome associated with? | Aspirin
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| True or False: There is a reversal to aspirin-related bleeding. | False
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| What are S/S of Reye's syndrome? | Encephalopathy and fatty liver degeneration
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| What illness are Reye's syndrome associated with? | Influenza and chicken pox
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| What is an effective method for preventing Reye's syndrome? | Don't give aspirin to children younger than 12 years
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| What is an example of a second generation NSAID? | Celebrex
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| Does acetaminophen have any anti-inflammatory actions? | No
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| Is acetaminophen considered an NSAID? | No
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| Is acetaminophen associated with Reye's syndrome? | No
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| What is the treatment for an acetaminophen overdose? | Acetylcysteine (Mucomyst), which is usually nebulized
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| How does the AHA recommended using COX inhibitors? | In a stepped-care approach
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| Which COX inhibition is associated with an increased risk of MI and stroke? | COX-2
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