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COX Inhibitors

Pharmacology

QuestionAnswer
What are the general adverse effects of COX inhibitors? Gastric ulceration, bleeding, and renal impairment
What dose of aspirin is used prophylactically for CHF? 81 mg
What are some other uses of aspirin other than DVT prevention? Prevention of Alzheimer's disease and cancer (colorectal)
What are first generation NSAIDs used for? To treat inflammatory disorders (e.g., rheumatoid arthritis)
What is a major adverse effect of first generation NSAIDs? GI ulceration
What are S/S of aspirin toxicity? Tinnitus, sweating, headache, and dizziness; progresses to respiratory depression, hyperthermia, dehydration, and acidosis
Why is aspirin contraindicated in pregnancy? Maternal anemia and post-partum hemorrhage
Which COX inhibitor is Reye's syndrome associated with? Aspirin
True or False: There is a reversal to aspirin-related bleeding. False
What are S/S of Reye's syndrome? Encephalopathy and fatty liver degeneration
What illness are Reye's syndrome associated with? Influenza and chicken pox
What is an effective method for preventing Reye's syndrome? Don't give aspirin to children younger than 12 years
What is an example of a second generation NSAID? Celebrex
Does acetaminophen have any anti-inflammatory actions? No
Is acetaminophen considered an NSAID? No
Is acetaminophen associated with Reye's syndrome? No
What is the treatment for an acetaminophen overdose? Acetylcysteine (Mucomyst), which is usually nebulized
How does the AHA recommended using COX inhibitors? In a stepped-care approach
Which COX inhibition is associated with an increased risk of MI and stroke? COX-2
Created by: shrewsburysd