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Week 8: Human Genetics and Biotechnology

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Question
Answer
gene regulation   the various systems that control and determine which genes are switched on and off, and when, how long, and to what extent the genes are expressed.  
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color blindness   visual defect resulting in the inability to distinguish colors and is usually an inherited sex  
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Cystic fibrosis   an inherited condition that affects the cells that produce mucus, sweat and digestive juices; a defective gene causes the secretions to become thick and sticky; the secretions plug up tubes, ducts and passageways, especially in the lungs and pancreas.  
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Down's Syndrome   A human genetic disease resulting from having an extra chromosome 21, characterized by mental retardation and heart and respiratory defects  
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hemophilia   genetic disorder that impairs the blood's ability to clot and can cause excessive bleeding  
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Huntington's Disease   autosomal dominant, inherited adult inherited adult-onset disease of the central nervous system  
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incomplete dominance   neither allele is dominant; a blending of the two create a new phenotype  
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karyotype   A method of organizing the chromosomes of a cell in relation to number, size, and type  
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nondisjunction   an accident of meiosis or mitosis, in which both members of a pair of homologous chromosomes or both sister chromatids fail to move apart properly  
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Pedigree   A family tree describing the occurrence of heritable characters in parents and offspring across as many generations as possible.  
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PKU   inherited absence of phenylalanine hydroxylase (an enzyme that converts phenylalanine into tyrosine). Phenylalanine accumulates in blood and seriously impairs early neuronal development. The defect can be controlled by diet.  
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polygenic traits   an additive effect of two or more gene loci on a single phenotypic character.  
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Sex-linked trait   An inherited trait, such as color discrimination, determined by a gene located on a sex chromosome and that therefore shows a different pattern of inheritance in males and females  
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Sickle Cell Anemia   a disease passed down through families in which red blood cells form an abnormal sickle or crescent shape. Red blood cells carry oxygen to the body and are normally shaped like a disc.  
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biotechnology   The industrial use of living organisms or their components to improve human health and food production.  
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Bt corn   a genetically modified organism (GMO) which has been bioengineered to resist the European corn borer, a crop pest which can cause significant damage to crops  
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cloning   to make one or more genetic replicas of an individual or cell.  
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DNA fingerprint   A method used to identify DNA banding patterns that are specific to an individual or for comparing the nucleotide sequences of fragments of DNA from different sources.  
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gel electrophoresis   the separation of nucleic acids or proteins, on the basis of their size and electrical charge, by measuring their rate of movement through an electrical field in a gel.  
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gene therapy   The transplantation of normal genes into cells in place of missing or defective ones in order to correct genetic disorders.  
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genetically modified organism   an organism whose genetic material has been altered  
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genomics   The branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.  
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Human Genome Project   An international project to map the entire genetic material of a human being  
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plasmid   A small ring of DNA that carries accessory genes separate from those of a bacterial chromosome  
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recombinant DNA   A DNA molecule made in vitro with segments from different sources  
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restriction enzyme   An enzyme that catalyzes the cleavage of DNA at specific locations , producing small fragments used in gene splicing for DNA technology.  
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