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tricyclic antidepressants

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TCAs: prototype Amytriptyline others: imipramine, doxepin, nortriptyline, amoxapine, trimipramine, desipramine, clomipramine   TX: depression, depressive episodes of bipolar disorders other uses: neyropathic pain, fibromyalgia, anxiety disorders, OCD, insomnia, ADHD  
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TCAs complications   Orthostatic hypotention, anticholiergic effects, sedation, toxicity, decreased seizure threshold, excessive sweating  
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anticholinergic effects   dry mouth, blurred vision, photophobia, urinary hesitancy or retention, constipation, tachycardia.  
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TCAs contraindications/precautions   don't give to clients w/seizures disorder or w/ myocardial infarction. cautious w/elderly or clients w/CAD, diabetes, liver, kidney, or resp. disorders, urinary retention or obstruction, angle-closure glaucoma, benighn hyperplasia, hyperthyroidism. preg  
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TCAs interactions   avoid concurrent use w/MAOIs, St. John's Wort (can lead to serotonin syndrome), antihistamines, other anticholinergic agents, epinephrine dopamine, ephedrine amphetamine, alcohol, opioids, benzodiazepines  
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