Chapter 15, The Paramedic by Will Chapleau
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Study of Drugs | Pharmacology
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Study of how drugs are deliverd to and from affected organs. | Pharmacokinetics
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How readily or easily the drug is able to combine substances such as water or oil. | Solubility
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Study of how drugs interact with the living tissues in the body. | Pharmacodynamics
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4 Ways Drugs can act | 1. Bind to a receptor site. 2 Change physical properties of the cell.3 Chemically combine with other chemicals. 4.Alter a normal metabolic pathway
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A Substance added to a drug perparation to provide for or enhance delivery of the drug into body tissues | Vehicle
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Routes of Administration | 1.Enteral-Orally2.Parenteral-IM,IV,IO,SC,SQ3.Topical.
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Subroutes of Administration | Ingestion.Injection.Absorbtion.Inhalation.
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Process of handling medications that require the maintaining of sterility is.. | Asepsis (Without germs or pathogens)
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Progress from its pharmaceutical dosage form to a biologically available substance | Drug Absorption
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Factors that affect drug absorption | Solubility.Concentration.pH. Site of absorption.Blood supply. Bioavailability
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Solute vs Solvent | Solute = Drug.Solvent = Liquid in which it is dissolved
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Drug Forms | Liquids.Solids.Suppositories.Inhalants.Sprays.Creams/lotions.Patches,Lozenges.
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Factors that affect distribution | Cardiovascular function.Regional blood flow.Drug storage reservoirs.Physiological barriers
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2 Effects with Biotransformation | 1.Transform the drug into a more or less active metabolite.2.Make the drug more water soluble for elimination
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Passage of a drug through the liver and the renal (kidney) circulation resulting in chemical alterations and elimination of some of the drug from the body. | First Pass Effect
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Amount of drug available for the body to use following biotransformation and first pass events | Bioavailability
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2 Reasons why Bioavailability can be altered | 1.Absorption is reduced.2 Elimination occurs prior to entering the systemic circulation.
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5 Patient Rights | 1.Patient.2.Drug.3.Dose.4.Route.5.Time.
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Primary neurotransmitter for the Sympathetic Nervous System. | Norepinephrine.Also Epinephrine and Dopamine
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Neurotransmitter for the Parasympathetic Nervous System | Acetylcholine
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A drug that inhibits ACE (angiotensin converting enzyme) which is important to the formation of angiotensin II. Lowers Blood Pressure | ACE Inhibitors
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Drugs that mimic the effects of the sympathetic nervous system. | Sympathomimetic
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Class of drug that blocks the effects of the parasympathetic nervous system. | Parasympatholytic. Atropine...
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Which type of receptor binding results in increased heart rate, force of contraction and conduction velocity | Beta 1
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Class of medication that prevents thrombi by interrupting the clotting cascade | Anticoagulants
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An untoward effect after adminstering succinylcholine for a Rapid Sequence Intubation procedure? | Hypotension
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Organophosphate Poisoning causes the inhibition of acetylcholinesterase (AChE), an accumulation of acetylcholine (ACh), and profound parasympathetic effects. What class of drugs would be used to reverse these effects | Anticholinergics
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Proteins present on a cell membrane to which a drug must bind in order to elicit a desired respnose | Drug Receptor
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Power of a drug to produce a therapeutic effect | Efficacy
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Medications that stimulate the sympathetic system | Sympatohmimetics
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Medications that inhibit the sympathetic system | Sympatholytics
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Location where Sympathetic and Parasympathetic arises. | Sympathetic - Thoraic, Lumbar.Parasympathetic - Brain Stem, Sacral segments.
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Medications that block the actions of the parasympathetic system | Parasympatholytics
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Medications that stimulate the parasympathetic system | Parasympathomimetics.
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Results from stimulating the Parasympathetic system | Pupil Constrction.Secretion by digestive glands.Increase Smooth Muscle activity.Bronchoconstriction.Reduce HR and contractile force.
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Special Considerations in drug therapy | 1.Geriatric.2.Peds.3 Pregos.
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Enhancement of one agent by another so that the combined effect is greater than the sum of the effects of each one alone | Potentiation
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The gradual adaptation to a stimulus or to the environment, with a decreasing response. | Habituation
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-olol | Beta Blockers
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-pril | ACE Inhibitors
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-ipines | Calcium Channel Blocker
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