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Chapter 15, The Paramedic by Will Chapleau

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Answer
Study of Drugs   Pharmacology  
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Study of how drugs are deliverd to and from affected organs.   Pharmacokinetics  
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How readily or easily the drug is able to combine substances such as water or oil.   Solubility  
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Study of how drugs interact with the living tissues in the body.   Pharmacodynamics  
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4 Ways Drugs can act   1. Bind to a receptor site. 2 Change physical properties of the cell.3 Chemically combine with other chemicals. 4.Alter a normal metabolic pathway  
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A Substance added to a drug perparation to provide for or enhance delivery of the drug into body tissues   Vehicle  
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Routes of Administration   1.Enteral-Orally2.Parenteral-IM,IV,IO,SC,SQ3.Topical.  
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Subroutes of Administration   Ingestion.Injection.Absorbtion.Inhalation.  
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Process of handling medications that require the maintaining of sterility is..   Asepsis (Without germs or pathogens)  
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Progress from its pharmaceutical dosage form to a biologically available substance   Drug Absorption  
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Factors that affect drug absorption   Solubility.Concentration.pH. Site of absorption.Blood supply. Bioavailability  
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Solute vs Solvent   Solute = Drug.Solvent = Liquid in which it is dissolved  
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Drug Forms   Liquids.Solids.Suppositories.Inhalants.Sprays.Creams/lotions.Patches,Lozenges.  
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Factors that affect distribution   Cardiovascular function.Regional blood flow.Drug storage reservoirs.Physiological barriers  
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2 Effects with Biotransformation   1.Transform the drug into a more or less active metabolite.2.Make the drug more water soluble for elimination  
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Passage of a drug through the liver and the renal (kidney) circulation resulting in chemical alterations and elimination of some of the drug from the body.   First Pass Effect  
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Amount of drug available for the body to use following biotransformation and first pass events   Bioavailability  
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2 Reasons why Bioavailability can be altered   1.Absorption is reduced.2 Elimination occurs prior to entering the systemic circulation.  
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5 Patient Rights   1.Patient.2.Drug.3.Dose.4.Route.5.Time.  
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Primary neurotransmitter for the Sympathetic Nervous System.   Norepinephrine.Also Epinephrine and Dopamine  
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Neurotransmitter for the Parasympathetic Nervous System   Acetylcholine  
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A drug that inhibits ACE (angiotensin converting enzyme) which is important to the formation of angiotensin II. Lowers Blood Pressure   ACE Inhibitors  
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Drugs that mimic the effects of the sympathetic nervous system.   Sympathomimetic  
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Class of drug that blocks the effects of the parasympathetic nervous system.   Parasympatholytic. Atropine...  
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Which type of receptor binding results in increased heart rate, force of contraction and conduction velocity   Beta 1  
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Class of medication that prevents thrombi by interrupting the clotting cascade   Anticoagulants  
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An untoward effect after adminstering succinylcholine for a Rapid Sequence Intubation procedure?   Hypotension  
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Organophosphate Poisoning causes the inhibition of acetylcholinesterase (AChE), an accumulation of acetylcholine (ACh), and profound parasympathetic effects. What class of drugs would be used to reverse these effects   Anticholinergics  
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Proteins present on a cell membrane to which a drug must bind in order to elicit a desired respnose   Drug Receptor  
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Power of a drug to produce a therapeutic effect   Efficacy  
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Medications that stimulate the sympathetic system   Sympatohmimetics  
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Medications that inhibit the sympathetic system   Sympatholytics  
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Location where Sympathetic and Parasympathetic arises.   Sympathetic - Thoraic, Lumbar.Parasympathetic - Brain Stem, Sacral segments.  
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Medications that block the actions of the parasympathetic system   Parasympatholytics  
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Medications that stimulate the parasympathetic system   Parasympathomimetics.  
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Results from stimulating the Parasympathetic system   Pupil Constrction.Secretion by digestive glands.Increase Smooth Muscle activity.Bronchoconstriction.Reduce HR and contractile force.  
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Special Considerations in drug therapy   1.Geriatric.2.Peds.3 Pregos.  
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Enhancement of one agent by another so that the combined effect is greater than the sum of the effects of each one alone   Potentiation  
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The gradual adaptation to a stimulus or to the environment, with a decreasing response.   Habituation  
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-olol   Beta Blockers  
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-pril   ACE Inhibitors  
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-ipines   Calcium Channel Blocker  
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