USMLE Step 1 drug toxicities
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Atropine-like side effects | Tricyclics
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| Coronary vasospasm | Cocaine, sumatriptan
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| Cutaneous flushing | Niacin, Ca2+ channel blockers, adenosine, vancomycin
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| Dilated cardiomyopathy | Doxorubicin, daunorubicin
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| Torsades de pointes | Class III (sotalol), class IA (quinidine) antiarrhythmics, cisapride
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| Agranulocytosis | Clozapine, carbamazepine, colchicine, propylthiouracil, methimazole
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| Aplastic anemia | Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole
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| Direct Coombs-positive hemolytic anemia | Methyldopa
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| Gray baby syndrome | Chloramphenicol
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| Hemolysis in G6PD-deficient patients | Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin ("hemolysis IS PAIN")
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| Megaloblastic anemia | Phenytoin, Methotrexate, Sulfa drugs ("having a BLAST with PMS")
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| Thrombotic complications | OCPs (estrogens and progestins)
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| Cough | ACE inhibitors
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| Pulmonary fibrosis | Bleomycin, busulfan, amiodarone
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| Acute cholestatic hepatitis | Macrolides
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| Focal to massive hepatic necrosis | Halothane, valproic acid, acetaminophen, Amanita phalloides
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| Hepatitis | INH
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| Pseudomembranous colitis | Ampicillin, clindamycin
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| Adrenocortical insufficiency | Glucocorticoid withdrawal (HPA suppression)
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| Gynecomastia | Spironolactone, Digitalis, Cimedtidine, chronic Alcohol use, estrogens, Ketoconazole ("Some Drugs Create Awesome Knockers")
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| Hot flashes | Tamoxifen, clomiphene
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| Gingival hyperplasia | Phenytoin
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| Gout | Furosemide, thiazides
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| Osteoporosis | Corticosteroids, heparin
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| Photosensitivity | Sulfonamides, Amiodarone, Tetracycline ("SAT for a PHOTO")
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| Rash (Stevens-Johnson syndrome) | Ethosuximide, lamotrigine, carbamazepine, phenobarbital, phenytoin, sulfa drugs, penicillin, allopurinol
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| SLE-like syndrome | Hydralazine, INH, Procainamide, Phenytoin ("it's not HIPP to have lupus")
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| Tendonitis, tendon rupture, and cartilage damage (kids) | Fluoroquinolones
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| Fanconi's syndrome | expired tetracyclines
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| Interstitial nephritis | Methicillin, NSAIDs, furosemide
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| Hemorrhagic cystitis | Cyclophosphamide, ifosfamide (prevent by coadministering with mesna)
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| Cinchonism | Quinidine, quinine
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| Diabetes insipidus | Lithium, demeclocycline
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| Parkinson-like syndrome | Haloperidol, chlorpromazine, reserpine, metoclopramide
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| Seizures | Bupropion, imipenem/cilastatin, isoniazid
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| Tardive dyskinesia | Antipsychotics
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| Disulfiram-like reaction | Metronidazole, certain cephalosporins, procarbazine, 1-st generation sulfonylureas
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| Nephrotoxicity / neurotoxicity | Polymyxins
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| Nephrotoxicity / ototoxicity | Aminoglycosides, vancomycin, loop diuretics, cisplatin
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