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USMLE_DrugTox
USMLE Step 1 drug toxicities
| Question | Answer |
|---|---|
| Atropine-like side effects | Tricyclics |
| Coronary vasospasm | Cocaine, sumatriptan |
| Cutaneous flushing | Niacin, Ca2+ channel blockers, adenosine, vancomycin |
| Dilated cardiomyopathy | Doxorubicin, daunorubicin |
| Torsades de pointes | Class III (sotalol), class IA (quinidine) antiarrhythmics, cisapride |
| Agranulocytosis | Clozapine, carbamazepine, colchicine, propylthiouracil, methimazole |
| Aplastic anemia | Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole |
| Direct Coombs-positive hemolytic anemia | Methyldopa |
| Gray baby syndrome | Chloramphenicol |
| Hemolysis in G6PD-deficient patients | Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin ("hemolysis IS PAIN") |
| Megaloblastic anemia | Phenytoin, Methotrexate, Sulfa drugs ("having a BLAST with PMS") |
| Thrombotic complications | OCPs (estrogens and progestins) |
| Cough | ACE inhibitors |
| Pulmonary fibrosis | Bleomycin, busulfan, amiodarone |
| Acute cholestatic hepatitis | Macrolides |
| Focal to massive hepatic necrosis | Halothane, valproic acid, acetaminophen, Amanita phalloides |
| Hepatitis | INH |
| Pseudomembranous colitis | Ampicillin, clindamycin |
| Adrenocortical insufficiency | Glucocorticoid withdrawal (HPA suppression) |
| Gynecomastia | Spironolactone, Digitalis, Cimedtidine, chronic Alcohol use, estrogens, Ketoconazole ("Some Drugs Create Awesome Knockers") |
| Hot flashes | Tamoxifen, clomiphene |
| Gingival hyperplasia | Phenytoin |
| Gout | Furosemide, thiazides |
| Osteoporosis | Corticosteroids, heparin |
| Photosensitivity | Sulfonamides, Amiodarone, Tetracycline ("SAT for a PHOTO") |
| Rash (Stevens-Johnson syndrome) | Ethosuximide, lamotrigine, carbamazepine, phenobarbital, phenytoin, sulfa drugs, penicillin, allopurinol |
| SLE-like syndrome | Hydralazine, INH, Procainamide, Phenytoin ("it's not HIPP to have lupus") |
| Tendonitis, tendon rupture, and cartilage damage (kids) | Fluoroquinolones |
| Fanconi's syndrome | expired tetracyclines |
| Interstitial nephritis | Methicillin, NSAIDs, furosemide |
| Hemorrhagic cystitis | Cyclophosphamide, ifosfamide (prevent by coadministering with mesna) |
| Cinchonism | Quinidine, quinine |
| Diabetes insipidus | Lithium, demeclocycline |
| Parkinson-like syndrome | Haloperidol, chlorpromazine, reserpine, metoclopramide |
| Seizures | Bupropion, imipenem/cilastatin, isoniazid |
| Tardive dyskinesia | Antipsychotics |
| Disulfiram-like reaction | Metronidazole, certain cephalosporins, procarbazine, 1-st generation sulfonylureas |
| Nephrotoxicity / neurotoxicity | Polymyxins |
| Nephrotoxicity / ototoxicity | Aminoglycosides, vancomycin, loop diuretics, cisplatin |
Created by:
Forbachc
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