Chapter 40 Systemic Lupus Erythematosus
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| Systemic Lupus Erythematosus (SLE) | Chronic multisystem inflammatory disease
Associated with abnormalities of immune system
Affects skin, joints, lungs, heart, and renal, hematologic, and neurologic systems
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| Systemic Lupus Erythematosus (SLE) Pathophysiology | Disordered T-cell function leading to hyperactive B cells
Autoantibodies against normal body components
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| Systemic Lupus Erythematosus Manifestations | Fever, anorexia, weight loss, multiple arthralgias/symmetric polyarthritis
Unexplained fever
Red rash, especially on the face
Alopecia
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| Systemic Lupus Erythematosus Manifestations | Pale, cyanotic fingers/toes (vasculitis manifestation)
Peripheral/periorbital edema (renal manifestation)
Sensitivity to sunlight
Cognitive dysfunction (neurological manifestations)
Mouth ulcerations
Enlarged glands
Extreme Fatigue
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| Systemic Lupus Erythematosus Complications | Kidney failure and infections are leading cause of death
Infection
Fever should be considered serious: It is classic sign of exacerbation
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| Warning Signs of SLE FLARE | Increased fatigue
Pain, abdominal discomfort
Rash
Headache
Fever
dizziness
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| SLE Diagnostic Studies | patient history
physical examination
laboratory findings:
ANA, anti-DNA antibody testing, ESR, Serum complement levels, CBC, Urinalysis, Kidney biopsy
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| SLE Drug Therapy | NSAIDs
Antimalarial drugs ( skin/arthritic manifestations)
Corticosteroid therapy ( severe/life-threatening manifestations)
High doses, also may be indicated for long term
More complications possible due to steroid therapy
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| SLE Treatments | Avoid Sun exposure
Avoid oral contraceptive use
Complications: Renal
Hemodialysis or peritoneal dialysis
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