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RNSG 1343 SLE
Chapter 40 Systemic Lupus Erythematosus
Question | Answer |
---|---|
Systemic Lupus Erythematosus (SLE) | Chronic multisystem inflammatory disease Associated with abnormalities of immune system Affects skin, joints, lungs, heart, and renal, hematologic, and neurologic systems |
Systemic Lupus Erythematosus (SLE) Pathophysiology | Disordered T-cell function leading to hyperactive B cells Autoantibodies against normal body components |
Systemic Lupus Erythematosus Manifestations | Fever, anorexia, weight loss, multiple arthralgias/symmetric polyarthritis Unexplained fever Red rash, especially on the face Alopecia |
Systemic Lupus Erythematosus Manifestations | Pale, cyanotic fingers/toes (vasculitis manifestation) Peripheral/periorbital edema (renal manifestation) Sensitivity to sunlight Cognitive dysfunction (neurological manifestations) Mouth ulcerations Enlarged glands Extreme Fatigue |
Systemic Lupus Erythematosus Complications | Kidney failure and infections are leading cause of death Infection Fever should be considered serious: It is classic sign of exacerbation |
Warning Signs of SLE FLARE | Increased fatigue Pain, abdominal discomfort Rash Headache Fever dizziness |
SLE Diagnostic Studies | patient history physical examination laboratory findings: ANA, anti-DNA antibody testing, ESR, Serum complement levels, CBC, Urinalysis, Kidney biopsy |
SLE Drug Therapy | NSAIDs Antimalarial drugs ( skin/arthritic manifestations) Corticosteroid therapy ( severe/life-threatening manifestations) High doses, also may be indicated for long term More complications possible due to steroid therapy |
SLE Treatments | Avoid Sun exposure Avoid oral contraceptive use Complications: Renal Hemodialysis or peritoneal dialysis |