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Chapter 40 Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE)  Chronic multisystem inflammatory disease  Associated with abnormalities of immune system  Affects skin, joints, lungs, heart, and renal, hematologic, and neurologic systems
Systemic Lupus Erythematosus (SLE) Pathophysiology  Disordered T-cell function leading to hyperactive B cells  Autoantibodies against normal body components
Systemic Lupus Erythematosus Manifestations  Fever, anorexia, weight loss, multiple arthralgias/symmetric polyarthritis  Unexplained fever  Red rash, especially on the face  Alopecia
Systemic Lupus Erythematosus Manifestations  Pale, cyanotic fingers/toes (vasculitis manifestation)  Peripheral/periorbital edema (renal manifestation)  Sensitivity to sunlight  Cognitive dysfunction (neurological manifestations)  Mouth ulcerations  Enlarged glands  Extreme Fatigue
Systemic Lupus Erythematosus Complications  Kidney failure and infections are leading cause of death  Infection  Fever should be considered serious: It is classic sign of exacerbation
 Warning Signs of SLE FLARE  Increased fatigue  Pain, abdominal discomfort  Rash  Headache  Fever  dizziness
SLE Diagnostic Studies  patient history  physical examination  laboratory findings:  ANA, anti-DNA antibody testing, ESR, Serum complement levels, CBC, Urinalysis, Kidney biopsy
SLE Drug Therapy  NSAIDs  Antimalarial drugs ( skin/arthritic manifestations)  Corticosteroid therapy ( severe/life-threatening manifestations)  High doses, also may be indicated for long term  More complications possible due to steroid therapy
SLE Treatments  Avoid Sun exposure  Avoid oral contraceptive use  Complications: Renal  Hemodialysis or peritoneal dialysis
Created by: pdimple