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Degenerative Neuromuscular Disorders

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Question
Answer
Parkinson's Disease   Affecting brain; loss of dopamine; loss of ability to control and initiate movement.  
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Multiple Sclerosis   - Affecting brain and spinal cord; scarring of myelin sheath - Decreased nerve conduction - Loss of motor, sensory, cerebellar function, emotional lability  
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ALS (Amyotrophic Lateral Sclerosis)   - Degeneration of upper/lower motor neurons of brain stem and spinal cord - Progressive muscle weakness, atrophy, deterioration  
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Gillian-Barre' Syndrome   - Acute attack on peripheral nervous system - Inflammation causes ascending muscle weakness, paralysis and paresthesia  
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Myasthenia Gravis   - Attach on acetylcholine (Ach) receptors - Prevents acetylcholine from stimulating skeletal muscle contraction - No sensory loss  
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Parkinson's Disease complications   - Dysphagia, nutritional problem, loss of spontaneous movement, immobility, falls, pneumonia, dementia  
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Parkinson's Disease S&S   Rigidity, tremors at rest, decreased arm swing, bradykinesia, stooped, shuffling, difficulty initiating movement  
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Multiple Sclerosis S&S   Fatigue, motor weakness, bowel & bladder incontinence, diplopia, paresthesia, sexual dysfunction, spasticity, emotional lability  
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Multiple Sclerosis complications   - Immobility, UTI, pneumonia, depression  
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ALS S&S    
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ALS Complications   - Paralysis - Respiratory failure - Death from respiratory failure in 3 years  
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Gillian-Barre' Syndrome S&S   Ascending bilateral weakness and paresthesia of legs progressing upward to include trunk and respiratory muscles.  
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Myasthenia Gravis S&S   Descending muscle weakness, eye/mouth drooping, decreased arm strength, may progress to respiratory fatigue  
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Gillian-Barre' Syndrome complication   Paralysis, aspiration, autonomic nervous system involvement, dysrhythmias, respiratory failure  
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Myasthenia Gravis complication   - Respiratory failure - Myasthenia crisis (increased muscle weakness) caused by missing medication - Cholinergic crisis: too many myasthenia meds causing cholinergic effects (NVD, sweating, salivation, weakness, bradycardia  
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