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Pharm T3missed

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Question
Answer
Proton Pump Inhib given when   30-60min before meal  
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Fenofibrate-R   PPAR alpha  
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Cyclosporine   highest variability bioavailability, not eliminated in urine, not recycled in GI  
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When acute rejection doesn't respond to Corticosteroid tx   use Muromab CD3  
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Metformin   Tx for TypeIIDM, post [Cr] eval  
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"honeymoon" phase of TIDM dose   1/2 nl  
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TIDM the DCCTrial showed that   3+ injection/d-> dec LT complications  
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LMWH   has more predictable Anti-coag response  
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Highest glucocort v. mineralcort ratio   Dexamethasone  
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Asthma not tx with   H1 Antagonist  
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Nicotinic acid [AntiHyperlipidemic]   MOA depends on dec lipolysis and FFA release  
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Amylin mimetic [pramlintide]   peptide sec w/ insulin, inject b4 meal to dec Glu post meal  
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Acarbose   post prandial Hyperglycemia tx  
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Nicotinic acid [AntiHyperlipidemic]   least dependent on Hepatic LDL-R upregulation  
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Fenofibrate+Nicotinic acid   Pt w/TG>500mg/dL, need dec acute Pancreatitis  
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Ferrous SO4[o]   multi-pharm pt w/ anemia Fe<30  
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Pt 10yr diab hist, fast H-Glu, inj 2x/d, NPH+reg b4 dinner. Problems with low Glu   change time of NPH b4 bed  
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Smoker, essential HTN, LDL 150 w/ Simvastatin, dec to 130 w/   Ezetimibe add to simvastatin  
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Seasonal allergy on cimetidene [P450 inhibitor]   tx w/ Fexofenadin  
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inc LDL, want pregnancy, Fam Hist MI, essent HTN, dec HDL   tx w/ Colesevelam  
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Hursutism, gingival Hyperplasia, renal transplant   AE of Cyclosporin  
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OsteoArth, inc menses, Hct=31, no ulcer   tx w/ Indomethacin  
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Fe toxicity   tx w/ Deferoxamine, not Citrate  
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inc A1c, SFU+Metformin, favored 'add on" target post meal hyperGlu   Exenatide  
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Allergy, truck driver, Hist-R Antagonist   Loratidine  
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N/V, coffee grounds, peptic ulcer, no H. Pylori   tx w/ Omeprazole  
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inc Cholest, inc K+, dark urine myoglobin, inc CK, AE of   Simvastatin  
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Gout<1.3mg/dL, no urate stone but kidney stone   tx w/ Indomethacin  
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Gout inc Freq and severity, 8mg   Ibuprofen+Probenicid  
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Rapid Anti-coag, prevent DVT in prior Hep-induced Thrombocyt   Bivalirubin IV  
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TIDM, inc risk of hypoGlu, need post-prandial insulin flexibility   Subst Lispro for Reg  
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TIDM, inc risk of hypoGlu, need basal insulin   Subst Glargine for NPH  
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Which AE is there no tolerance to   miosis  
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hypokalemia, HTN, dec renin, HyperCort   tx w/ spironolactone  
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tx w/ Sumatriptan failed acutely-> headache   Subst tx w/ Elitriptan[acutely]/TCA amitryptin [prophylaxis]  
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Thiaolidine+Rosiglitazone   inc risk of ht attack, MOA dec insulin Resist and dec FFA  
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Biguanide/Metformin   inhibit Hepatic GNG thru activating AMPK  
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SFU[glipizide]   Ca channle blker and Diuretic interfere with MOA  
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Metformin   does not lead to wt gain or hypoglycemia  
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Metformin   1st line Type 2 DM  
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Induction phase of Immunosuppression   Corticosteroid, MM, Tacrolimus  
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Opioids   do not activate Glumate[E]-R  
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Opioids   dec Ca conduction, dec cAMP, inc K conduction, activat Gi/o  
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LMWH   require AT III, have a long t1/2, lesser inhib of Thromb, dec thrombocytopenia risk  
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Anti-Inflammatory inject directly to joint   Triamcinolone Acetamide  
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Flutamide   dec Androgen activation at R  
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Flutamide   does not dec 5aReductase, dec FSH/LH/GnRH  
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Acarbose   specifically target post meal HyperGlu in pre-diabetics  
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Celecoxib   tx underlying coz of OA in Pt wit Hx PUD  
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multi-pharm female w/ anemia   FeSO4 IM  
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Chronic tx for IBD/UC   Mesalamine 5-ASA  
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M. Relaxers given with fentanyl to dec   Truncal rigidity  
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Greatly dec LDL, mild dec TG and vLDL   Rosuvastatin  
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Confirmatory test for Gout v other inflamm dz   Colchicine  
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Metformin   AE: inc risk of Metabolic Acidosis, temporary d/c if dye used  
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