teratogens
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show | 3-8 weeks
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show | Before 3 weeks: all-or-none, after 8 weeks: growth and function are affected
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show | fetal alcohol syndrome, mental retardation
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show | Renal damage
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show | abnormal fetal development and addication, placental abruption
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show | Vaginal clear cell adenocarcinoma
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show | congenital goiter, hypothyroidism
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show | Extremely high risk for spontaneous abortions, birth defects (cleft palate, cardiac abnormalities)
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show | Limb defects (flipper limbs)
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show | Pre-term labor, placental problems, IUGR, ADHD
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X-rays, anticonvulsants | show 🗑
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show | bone deformities, fetal hemorrhage, abortion
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show | discolored teeth
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show | absence of digits, multiple anomalies
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show | CN VIII toxicity
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Folate antagonists | show 🗑
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show | pre/post natal developmental retardation, microcephaly, holoprosencephaly, facial abnormalities, limb dislocation, heart/lung fistuals. Mechanism may include inhibition of cell migration.
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