Lutz CA
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| CNS Lymphoma | AIDS
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| Carribean, Japan | HTLV
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| Nasopharyngeal T cell lymphoma | EBV Asia, South America
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| B cell lymphoma | Hep C
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| MALT of stomach | H. Pylori
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| cutaneous MALT | Borrelia burgdorferi
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| t11;14 Mantle Cell Lphoma | BCL-1, prevent apoptosis
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| t14;18 Follicular Center Cell Lphoma | BCL-2, upreg prolif
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| stage determined CA | Hodgkins
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| CD 20+, 45+ | Lcyte Predominance Hodgkins
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| Females, mediastinum involved | Nodular sclerosis, 20-70% Hodgkins
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| CD 5, 20, 23 | SLL/CLL
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| CD 5, 20 | Mantle cell
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| CD 10, 20, 23 | Follicular cell
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| CD 20, 23 | Marginal zone, malt
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| t11;18 | Marginal zone, malt
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| lethal midline granuloma, Asia Central America | NK/T cell Lphoma; EBV CD56+
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| erythroderma+ blood involvement | Sezary Sx
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| cerebriform nuclei, Pautrier uabscess | Mycosis fungoides
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| aggressive, children, mediastinum, CD3, Tdt | Lblastic Lphoma
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| CD 30+, ALK+, t2;5 | Anaplastic large T cell Lphoma
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| <10% plasma cell, no lytic bone lesion | MGUS
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| m/c 1* bone CA, M protein, Bence-Jones, OAF | Mult Myeloma
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| B-pleated sheet, Congo red stain | Amyloid
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| Ig light chain | AL
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| SAA acute phase reactant | AA
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| m/c systemic amyloid, <60% PC, free light chain | AL
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| arthritis, RA, Chronic sepsis, slower>AL | AA
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| high SAA, elderly, ESRD, Crohn's, Chronic sepsis | poor prognosis
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| TB, mycobacteria, fungal, sarcoid | granuloma
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| monoclonal | CA causing virus
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| polyclonal | DNA methylation
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| CA causing viruses | HPV, EBV, HTLV
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| predicts clinical outcome well | stage
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| wt of detectable CA | 1g
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| cell # of detectable CA | 1 billion, 30 cell division
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| cell # to kill the pt | 1 kg, 1000 billion cell
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| CD 133+, blast crisis | CA stem cell
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| size of blood supply | 1mm req bl supply
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| dominant negative mutation | p53 tumor suppressor, one loss=CA
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| sis protooncogene | PDGF
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| autocrine cell growth w/ PDGF | astrocytoma, osteosarcoma
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| HER2/neu | EGF-R
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| breast CA, ovarian CA | HER2/neu R
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| ineffective EGF-R inhibitor | KRAS mutation
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| ret oncogene | thyroid carcinoma, MEN
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| loss of inhibitory abl domain | abl-bcr, CML
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| signal transduction in 15-20% of CA | ras
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| codon 12 13 | ras-GTP always active
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| GTPase Activating Protein, tumor suppressor | NF-1, degrade GTP->GDP
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| melanoma, NF | NF-1
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| lung CA, downregulate ras | LET7microRNA
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| transcription factors | C-myc, L-myc, N-myc
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| tumor suppressor, cell cycle regulator | Rb
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| bind E2F transcription factor | Rb
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| suppress cell cycle | Rb-E2F recruit HDACs
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| inc cyclin | inc prolif thru CDK->Rb-po4 + E2F
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| Rb inactivated in | retinoblastoma, osteosarcoma
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| Rb inactivated by | HPV
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| Knudson's hypothesis | 1 defective allele inherited, 1 more for CA
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| cyclin D1 activation | bcl-1 Mantle cell, t11;14
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| ATM | ataxia telangectasia
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| DNA repair proteins recruited by RAP80 | BRCA1, ABRA1
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| NER UV light | Xeroderma Pigmentosum
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| BER | smoking, reactive O2, bases go 1st
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| MMR | MSH2, MLH1; hi MSI-> Lynch Sx
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| HR | BRCA1, BRCA2 in breast, ovarian CA
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| prevent rasGTP-x->rasGDP | pt mut in codon 12 13 and NF-1
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| Ig heavy chain next to C-myc | t8;14 Burkitt Lphoma
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| acetylation of histone H3 H4 | activation
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| histone H3 Lys 4 methylation | active transcription
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| histone H3 Lys 9 methylation | inactive transcription
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| ALL1/MLL | Lys 4 methylator in ALL AML
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| Molec Mech #1 | APC/MUTYH loss, Kras mut, p53 loss
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| Molec Mech #1 | adenomatous polyp, M>F, Lt>rt, 60% spor, FAP
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| molec Mech #2 | CIMP, BRAF1 mut, hi MSI, methylated promoter, MGMT loss
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| molec Mech #2 | serrated polyp, F>M, Rt>lt, 20% spor
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| molec mech #3 | mut MSH2, 6, MLH1, PMS2, HNPCC/Lynch sx
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| FAP APC loss | benign polyp, 42 yo, Tx- proctolectomy
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| Lynch Sx | init adenoma, 48yo, Tx- colonoscopy
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| Apoptos Extrinsic pathway | TNF, Fas bind Init caspases-> Effector caspase
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| Apoptos Intrinsic pathway | Bak, Bax, Bim
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| anti- apop | Bcl-2 Bcl-x
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| Bcl-> cytC-> | Apaf-1-> Init caspase-> effector caspase
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| telomere sequence | TTAGGG
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| melanoma | neural crest origin, Slug TF.
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| sarcomas [bone] metastasize to | lung
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| lung carcinoma metastasize to | brain
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| colorectal CA metastasize to | liver
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