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Path- Eponyms T4-3
Lutz CA
| Question | Answer |
|---|---|
| CNS Lymphoma | AIDS |
| Carribean, Japan | HTLV |
| Nasopharyngeal T cell lymphoma | EBV Asia, South America |
| B cell lymphoma | Hep C |
| MALT of stomach | H. Pylori |
| cutaneous MALT | Borrelia burgdorferi |
| t11;14 Mantle Cell Lphoma | BCL-1, prevent apoptosis |
| t14;18 Follicular Center Cell Lphoma | BCL-2, upreg prolif |
| stage determined CA | Hodgkins |
| CD 20+, 45+ | Lcyte Predominance Hodgkins |
| Females, mediastinum involved | Nodular sclerosis, 20-70% Hodgkins |
| CD 5, 20, 23 | SLL/CLL |
| CD 5, 20 | Mantle cell |
| CD 10, 20, 23 | Follicular cell |
| CD 20, 23 | Marginal zone, malt |
| t11;18 | Marginal zone, malt |
| lethal midline granuloma, Asia Central America | NK/T cell Lphoma; EBV CD56+ |
| erythroderma+ blood involvement | Sezary Sx |
| cerebriform nuclei, Pautrier uabscess | Mycosis fungoides |
| aggressive, children, mediastinum, CD3, Tdt | Lblastic Lphoma |
| CD 30+, ALK+, t2;5 | Anaplastic large T cell Lphoma |
| <10% plasma cell, no lytic bone lesion | MGUS |
| m/c 1* bone CA, M protein, Bence-Jones, OAF | Mult Myeloma |
| B-pleated sheet, Congo red stain | Amyloid |
| Ig light chain | AL |
| SAA acute phase reactant | AA |
| m/c systemic amyloid, <60% PC, free light chain | AL |
| arthritis, RA, Chronic sepsis, slower>AL | AA |
| high SAA, elderly, ESRD, Crohn's, Chronic sepsis | poor prognosis |
| TB, mycobacteria, fungal, sarcoid | granuloma |
| monoclonal | CA causing virus |
| polyclonal | DNA methylation |
| CA causing viruses | HPV, EBV, HTLV |
| predicts clinical outcome well | stage |
| wt of detectable CA | 1g |
| cell # of detectable CA | 1 billion, 30 cell division |
| cell # to kill the pt | 1 kg, 1000 billion cell |
| CD 133+, blast crisis | CA stem cell |
| size of blood supply | 1mm req bl supply |
| dominant negative mutation | p53 tumor suppressor, one loss=CA |
| sis protooncogene | PDGF |
| autocrine cell growth w/ PDGF | astrocytoma, osteosarcoma |
| HER2/neu | EGF-R |
| breast CA, ovarian CA | HER2/neu R |
| ineffective EGF-R inhibitor | KRAS mutation |
| ret oncogene | thyroid carcinoma, MEN |
| loss of inhibitory abl domain | abl-bcr, CML |
| signal transduction in 15-20% of CA | ras |
| codon 12 13 | ras-GTP always active |
| GTPase Activating Protein, tumor suppressor | NF-1, degrade GTP->GDP |
| melanoma, NF | NF-1 |
| lung CA, downregulate ras | LET7microRNA |
| transcription factors | C-myc, L-myc, N-myc |
| tumor suppressor, cell cycle regulator | Rb |
| bind E2F transcription factor | Rb |
| suppress cell cycle | Rb-E2F recruit HDACs |
| inc cyclin | inc prolif thru CDK->Rb-po4 + E2F |
| Rb inactivated in | retinoblastoma, osteosarcoma |
| Rb inactivated by | HPV |
| Knudson's hypothesis | 1 defective allele inherited, 1 more for CA |
| cyclin D1 activation | bcl-1 Mantle cell, t11;14 |
| ATM | ataxia telangectasia |
| DNA repair proteins recruited by RAP80 | BRCA1, ABRA1 |
| NER UV light | Xeroderma Pigmentosum |
| BER | smoking, reactive O2, bases go 1st |
| MMR | MSH2, MLH1; hi MSI-> Lynch Sx |
| HR | BRCA1, BRCA2 in breast, ovarian CA |
| prevent rasGTP-x->rasGDP | pt mut in codon 12 13 and NF-1 |
| Ig heavy chain next to C-myc | t8;14 Burkitt Lphoma |
| acetylation of histone H3 H4 | activation |
| histone H3 Lys 4 methylation | active transcription |
| histone H3 Lys 9 methylation | inactive transcription |
| ALL1/MLL | Lys 4 methylator in ALL AML |
| Molec Mech #1 | APC/MUTYH loss, Kras mut, p53 loss |
| Molec Mech #1 | adenomatous polyp, M>F, Lt>rt, 60% spor, FAP |
| molec Mech #2 | CIMP, BRAF1 mut, hi MSI, methylated promoter, MGMT loss |
| molec Mech #2 | serrated polyp, F>M, Rt>lt, 20% spor |
| molec mech #3 | mut MSH2, 6, MLH1, PMS2, HNPCC/Lynch sx |
| FAP APC loss | benign polyp, 42 yo, Tx- proctolectomy |
| Lynch Sx | init adenoma, 48yo, Tx- colonoscopy |
| Apoptos Extrinsic pathway | TNF, Fas bind Init caspases-> Effector caspase |
| Apoptos Intrinsic pathway | Bak, Bax, Bim |
| anti- apop | Bcl-2 Bcl-x |
| Bcl-> cytC-> | Apaf-1-> Init caspase-> effector caspase |
| telomere sequence | TTAGGG |
| melanoma | neural crest origin, Slug TF. |
| sarcomas [bone] metastasize to | lung |
| lung carcinoma metastasize to | brain |
| colorectal CA metastasize to | liver |
Created by:
mcafej02
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