Benadryl
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| GENERIC NAME | Diphenhydramine
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| BRAND NAME | Benadryl
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| CLASS | Antihistamine,anticholinergic
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| MECHANISM OF ACTION | Blocks cellular histamine receptors; decreases vasodilation; decreases motion sickness. Reverses extrapyramidal reactions.
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| INDICATIONS | Symptomatic relief of allergies, allergic reactions, anaphylaxis, acute dystonic reactions (phenothiazines). Blood administration reactions; used for motion sickness, hay fever.
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| CONTRAINDICATIONS | Asthma, glaucoma, pregnancy, hypertension, narrow angle glaucoma, infants, patients taking monoamine oxidase inhibitors (MAOIs)
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| ADVERSE REACTIONS | Sedation. Hypotension, seizures, visual disturbances, vomiting, urinary retention, palpitations, arrhythmias, dry mouth and throat, and paradoxical CNS excitation in children.
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| NOTES ON ADMINISTRATION | Not used in infants or in pregnancy; Category B. If used in anaphylaxis, will be in conjunction with epinephrine, corticosteroids.
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| INCOMPATABILITIES/DRUG INTERACTIONS | Potentiates effects of alcohol, and other anticholinergics, may inhibit corticosteroid activity; MAOIs prolong anticholinergic effects of Diphenhydramine.
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| DOSE/ROUTE;Adult | 25-50mg IV, IM, or PO.
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| DOSE/ROUTE;Pediatric | 1-2 mg/kg IV. IO slowly, or IM. If given PO;5mg/kg/24 hours
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| ONSET OF ACTION | 15-30 minutes
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| PEAK EFFECTS | 1 hour
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| DURATION OF ACTION | 3-12 hours.
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| AZ DRUG BOX SUPPLY RANGE | 50 mg.
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