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Benadryl

QuestionAnswer
GENERIC NAME Diphenhydramine
BRAND NAME Benadryl
CLASS Antihistamine,anticholinergic
MECHANISM OF ACTION Blocks cellular histamine receptors; decreases vasodilation; decreases motion sickness. Reverses extrapyramidal reactions.
INDICATIONS Symptomatic relief of allergies, allergic reactions, anaphylaxis, acute dystonic reactions (phenothiazines). Blood administration reactions; used for motion sickness, hay fever.
CONTRAINDICATIONS Asthma, glaucoma, pregnancy, hypertension, narrow angle glaucoma, infants, patients taking monoamine oxidase inhibitors (MAOIs)
ADVERSE REACTIONS Sedation. Hypotension, seizures, visual disturbances, vomiting, urinary retention, palpitations, arrhythmias, dry mouth and throat, and paradoxical CNS excitation in children.
NOTES ON ADMINISTRATION Not used in infants or in pregnancy; Category B. If used in anaphylaxis, will be in conjunction with epinephrine, corticosteroids.
INCOMPATABILITIES/DRUG INTERACTIONS Potentiates effects of alcohol, and other anticholinergics, may inhibit corticosteroid activity; MAOIs prolong anticholinergic effects of Diphenhydramine.
DOSE/ROUTE;Adult 25-50mg IV, IM, or PO.
DOSE/ROUTE;Pediatric 1-2 mg/kg IV. IO slowly, or IM. If given PO;5mg/kg/24 hours
ONSET OF ACTION 15-30 minutes
PEAK EFFECTS 1 hour
DURATION OF ACTION 3-12 hours.
AZ DRUG BOX SUPPLY RANGE 50 mg.
Created by: klindley
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