Epinephrine
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| GENERIC NAME | Epinephrine
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| BRAND NAME | Adrenalin
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| CLASS | Sympathomimetic
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| MECHANISM OF ACTION | Direct acting alpha and beta-agonist. Alpha; Vasoconstriction. Beta-1; Positive inotropic, chronotropic, and dromtropic effects. Beta-2 bronchial smooth muscle relaxation and dilation of skeletal vasculature.
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| INDICATIONS | Cardiac arrest. symptomatic Bradycardia as an alternative infusion to dopamine, sever hypotension secondary to Bradycardia when atropine and transcutaneous pacing are unsuccessful. allergic reactions, anaphylaxis, asthma.
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| CONTRAINDICATIONS | Hypertension, hypothermia, pulmonary edema, myocardial ischemia, Hypovolemic shock.
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| ADVERSE REACTIONS | Hypertension, tachycardia, arrhythmias, pulmonary edema, anxiety, restlessness, psychomotor agitation, nausea, headache, angina.
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| NOTES ON ADMINISTRATION | Pregnancy safety; Category C. May cause syncope in asthmatic children. May increase myocardial oxygen demand.
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| INCOMPATABILITIES/DRUG INTERACTIONS | Potentiates other sympathomimetics, deactivated by alkaline solutions (i.e. sodium bicarbonate) monamine oxidase inhibitors may potentiate effects, beta blockers may blunt effects.
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| DOSE/ROUTE, Adult, Mild allergic reactions and asthma | 0.3-0.5 mg of 1;1000 SC.
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| Dose/Route, Ault Cardiac arrest | IV/IO dose 1 mg of 1;10,000 every 3-5 minutes during resuscitation. Follow each dose with 20 mL flush and elevate arm for 10-20 secs.
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| Dose/Route.Pediatric Mild allergic reactions and asthma | 0.01 mg/kg of 1;1,000 solution SC.
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| Dose/Route Pediatric Cardiac arrest | IV/IO dose 0.01 mg/kg of 1;10,000 solution every 3-5 minutes during arrest.
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| ONSET OF ACTION | Immediate.
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| PEAK EFFECTS | Minutes.
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| DURATION OF ACTION | Several minutes.
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| AZ DRUG BOX SUPPLY RANGE | 1:1,000 = 30 mg Multidose Vial.1:10,000 = 5 mg.
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| Dose/Route, Adult Anaphylaxis | 0.1mg of 1:10,000 IV/IO over 5 minutes
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| Dose/Route AdultHigher dose and what are the 2 indications | 0.2mg/kg may be used for beta blocker and calcium channel blocker overdose.
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| Dose/Route, Adultinfusion preperation and dose | Add 1mg of 1:1,000 solution to a 500ml bag of NS, or D5W. initial rate of 1mcg/min. titrated to effect. typical dose 2-10mcg/min
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| Dose/Route adult ET tube | 2-2.5mg diluted with 10ml NS
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| Dose/Route adultProfound Bradycardia or Hypotension | 2-10mcg/min titrate to patients response.
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| Dose/Route Pedeatric ET tube | 0.1 mg/kg of 1:1,000 solution
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| Dose/Route Pedeatric infusion dose | 0.1-1mcg/min titrate to patient response
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Created by:
klindley
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