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Epinephrine

QuestionAnswer
GENERIC NAME Epinephrine
BRAND NAME Adrenalin
CLASS Sympathomimetic
MECHANISM OF ACTION Direct acting alpha and beta-agonist. Alpha; Vasoconstriction. Beta-1; Positive inotropic, chronotropic, and dromtropic effects. Beta-2 bronchial smooth muscle relaxation and dilation of skeletal vasculature.
INDICATIONS Cardiac arrest. symptomatic Bradycardia as an alternative infusion to dopamine, sever hypotension secondary to Bradycardia when atropine and transcutaneous pacing are unsuccessful. allergic reactions, anaphylaxis, asthma.
CONTRAINDICATIONS Hypertension, hypothermia, pulmonary edema, myocardial ischemia, Hypovolemic shock.
ADVERSE REACTIONS Hypertension, tachycardia, arrhythmias, pulmonary edema, anxiety, restlessness, psychomotor agitation, nausea, headache, angina.
NOTES ON ADMINISTRATION Pregnancy safety; Category C. May cause syncope in asthmatic children. May increase myocardial oxygen demand.
INCOMPATABILITIES/DRUG INTERACTIONS Potentiates other sympathomimetics, deactivated by alkaline solutions (i.e. sodium bicarbonate) monamine oxidase inhibitors may potentiate effects, beta blockers may blunt effects.
DOSE/ROUTE, Adult, Mild allergic reactions and asthma 0.3-0.5 mg of 1;1000 SC.
Dose/Route, Ault Cardiac arrest IV/IO dose 1 mg of 1;10,000 every 3-5 minutes during resuscitation. Follow each dose with 20 mL flush and elevate arm for 10-20 secs.
Dose/Route.Pediatric Mild allergic reactions and asthma 0.01 mg/kg of 1;1,000 solution SC.
Dose/Route Pediatric Cardiac arrest IV/IO dose 0.01 mg/kg of 1;10,000 solution every 3-5 minutes during arrest.
ONSET OF ACTION Immediate.
PEAK EFFECTS Minutes.
DURATION OF ACTION Several minutes.
AZ DRUG BOX SUPPLY RANGE 1:1,000 = 30 mg Multidose Vial.1:10,000 = 5 mg.
Dose/Route, Adult Anaphylaxis 0.1mg of 1:10,000 IV/IO over 5 minutes
Dose/Route AdultHigher dose and what are the 2 indications 0.2mg/kg may be used for beta blocker and calcium channel blocker overdose.
Dose/Route, Adultinfusion preperation and dose Add 1mg of 1:1,000 solution to a 500ml bag of NS, or D5W. initial rate of 1mcg/min. titrated to effect. typical dose 2-10mcg/min
Dose/Route adult ET tube 2-2.5mg diluted with 10ml NS
Dose/Route adultProfound Bradycardia or Hypotension 2-10mcg/min titrate to patients response.
Dose/Route Pedeatric ET tube 0.1 mg/kg of 1:1,000 solution
Dose/Route Pedeatric infusion dose 0.1-1mcg/min titrate to patient response
Created by: klindley