Atropine Drug profile
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| GENERIC NAME | None
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| BRAND NAME | Atropine
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| CLASS | Anticholinergic agent
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| MECHANISM OF ACTION | Parasympatholytic; Inhibits action of acetylcholine at postganglionic parasympathetic neuroeffector sites. Increases HR in life threatening bradyarrhythmias.
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| INDICATIONS | Hemodynamically unstable Bradycardia, Asystole, Bradycardic (<60 beats a minute) PEA, Organophosphate poisoning, bronchospastic pulmonary disorders.
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| CONTRAINDICATIONS | Tachycardia, Hypersensitivity, unstable cardiovascular status in acute hemorrhage and myocardial ischemia, narrow-angle glaucoma.
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| ADVERSE REACTIONS | Headache, dizziness, Palpitations, N/V, Tachycardia, arrhythmias, anticholinergic effects (blurred vision, dry mouth, urinary retention), paradoxical Bradycardia when pushed slowly or at low doses, flushed, hot, dry skin.
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| NOTES ON ADMINISTRATION | Pregnancy category C, Moderate doses may cause pupil dilation.
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| INCOMPATABILITIES/DRUG INTERACTIONS | Potential adverse effects when administered with digoxin, cholinergics, physostigmine. Effects enhanced by antihistamines, procainamide, quinidine, antipsychotics, benzodiazepines, and antidepressants.
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| DOSE/ROUTE; Adult,Asystole and Bradycardic PEA | 1mg IV/IO push may repeat every 3-5 minutes up to 3 doses.
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| DOSE/ROUTE, ADULT, Unstable Bradycardia | 0.5 mg IV/IO every 3-5 minutes not to exceed 3mg total.
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| DOSE/ROUTE, ADULT, Organophosphate Poisoning | Extremely large doses (2-4mg or higher)
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| DOSE/ROUTE,PEDEATRIC | 0.02 mg/kg IV/IO push. May double for second dose. Minimum single dose is 0.1 mg.
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| DOSE/ROUTEChild | 0.02 mg/kg IV/IO push. May double for second dose. Maximum single dose in child is 0.5mg. Max total dose is 1mg
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| DOSE, Adolescent single dose | 1mg and total dose 2mg.
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| ONSET OF ACTION | Immediate
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| PEAK EFFECTS | Rapid to 1-2 minutes
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| DURATION OF ACTION | Duration 2-6 hours
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| AZ DRUG BOX SUPPLY RANGE | (4)prefilled 1mg syringes. Total 4mg (1)8mg Multidose vial.
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