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Atropine!

Atropine Drug profile

QuestionAnswer
GENERIC NAME None
BRAND NAME Atropine
CLASS Anticholinergic agent
MECHANISM OF ACTION Parasympatholytic; Inhibits action of acetylcholine at postganglionic parasympathetic neuroeffector sites. Increases HR in life threatening bradyarrhythmias.
INDICATIONS Hemodynamically unstable Bradycardia, Asystole, Bradycardic (<60 beats a minute) PEA, Organophosphate poisoning, bronchospastic pulmonary disorders.
CONTRAINDICATIONS Tachycardia, Hypersensitivity, unstable cardiovascular status in acute hemorrhage and myocardial ischemia, narrow-angle glaucoma.
ADVERSE REACTIONS Headache, dizziness, Palpitations, N/V, Tachycardia, arrhythmias, anticholinergic effects (blurred vision, dry mouth, urinary retention), paradoxical Bradycardia when pushed slowly or at low doses, flushed, hot, dry skin.
NOTES ON ADMINISTRATION Pregnancy category C, Moderate doses may cause pupil dilation.
INCOMPATABILITIES/DRUG INTERACTIONS Potential adverse effects when administered with digoxin, cholinergics, physostigmine. Effects enhanced by antihistamines, procainamide, quinidine, antipsychotics, benzodiazepines, and antidepressants.
DOSE/ROUTE; Adult,Asystole and Bradycardic PEA 1mg IV/IO push may repeat every 3-5 minutes up to 3 doses.
DOSE/ROUTE, ADULT, Unstable Bradycardia 0.5 mg IV/IO every 3-5 minutes not to exceed 3mg total.
DOSE/ROUTE, ADULT, Organophosphate Poisoning Extremely large doses (2-4mg or higher)
DOSE/ROUTE,PEDEATRIC 0.02 mg/kg IV/IO push. May double for second dose. Minimum single dose is 0.1 mg.
DOSE/ROUTEChild 0.02 mg/kg IV/IO push. May double for second dose. Maximum single dose in child is 0.5mg. Max total dose is 1mg
DOSE, Adolescent single dose 1mg and total dose 2mg.
ONSET OF ACTION Immediate
PEAK EFFECTS Rapid to 1-2 minutes
DURATION OF ACTION Duration 2-6 hours
AZ DRUG BOX SUPPLY RANGE (4)prefilled 1mg syringes. Total 4mg (1)8mg Multidose vial.
Created by: klindley