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Immunology Test - Chapter 1

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Term
Definition
Cells   __________ are at the heart of immune function.  
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10 trillion   The human body consists of approximately __________ cells.  
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fertilized egg cell   All cells are descended from a single type of cell, called the __________.  
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differentiation   This process, by which one type of cell becomes another, is called __________.  
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immune system, tissues they protect   The communication between cells of the __________ and the cells of the ___________ is critical to an understanding of immune function.  
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cell signalling   The major mechanisms by which cells transmit signals to each other, and how these signals are conveyed from the cell membrane to the nucleus to modulate gene expression, commonly referred to as __________.  
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secreted and membrane-bound mediators, proteins   The functions of cells of the immune system are dependent on a diverse array of __________, many of which are __________.  
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Pattern recognition receptors   __________ are required to bind to microbes to enable their detection and elimination.  
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Adhesion molecules, chemokine receptors   __________ and __________ are required to help immune cells migrate into the correct tissues.  
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Cytokines   __________ enable immune cells to send signals to each other.  
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Chemokines   __________ are required to recruit cells to a particular location.  
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two   There are __________ major arms of the immune response.  
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innate immunity   This quick-acting and powerful response is based on the recognition of key molecules commonly associated with many different types of invader using receptors that are encoded by the germline DNA, and only change very slowly over millennia by evolution.  
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adaptive immune response   Immunity that first emerged ~ 500 million years ago in the jawed fishes, and is now present in all vertebrate animals.  
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memory   Exposure to one organism could lead to enhanced defense against that organism if it should ever be encountered again.  
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innate   All lower animals make do solely with __________ immunity.  
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phagocytic cells   Cells of the innate immune system include __________.  
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anti-viral response   The __________ depends largely on signals that encourage nearby cells to shut down protein synthesis and switch on their own cellular defenses against viral infection.  
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Inflammation   __________ is the process of recruitment of white blood cells (leukocytes) and plasma proteins from the blood into the tissues to combat infection.  
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danger signals   Molecular motifs recognized by ancient, highly conserved receptors expressed on many different types of cell, including many cells not associated with the immune system.  
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recognition of "self" and "non-self" molecules   A key role played by the innate immune system is the __________.  
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pattern recognition receptors (or PRRs), pathogen-associated molecular patterns (PAMPs)   __________ detects __________ on non-self molecules, facilitating a defense response from the innate immune system.  
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no memory generated   The key limitation of the innate immune system it that there is __________ by exposure to a particular type of organism.  
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two   There are __________ key arms of the adaptive immune response.  
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Humoral, cell-mediated   The two key arms of the adaptive immune response are: __________ and __________.  
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antibodies   Bind to and neutralize microbes, produced by cells called B-lymphocytes.  
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B-lymphocytes   Antibodies are produced by the __________.  
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T-lymphocytes   Cell-mediated immunity, which is mediated by __________, serves to kill virally infected cells and also to control and regulate the immune responses of other cells.  
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Adaptive immunity, remember   __________ shows high specificity for target molecules and the ability to __________ previous encounters with particular microbes.  
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antigens   Highly diverse target molecules are termed __________.  
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DNA recombination   As there simply isn’t enough DNA in the human genome to code for the millions of possible receptors that are required for adaptive immunity to work, they must be prepared by the process of __________.  
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