Nonopioid Analgecics
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What actions do nonopioid analgesics have | anti-inflammatory, antipyretic, and analgesic action
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Examples of First generation NSAIDs Cox 1 and cox 2 inhibitors | aspirin, ibuprofen, naproxen, indomethacin, diclofenac, ketorolac, meloxicam
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Example of second generation NSAIDs cox 2 inhibitors | celecoxib
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What are the therapeutic uses | inflammation suppression, analgesia for mild-moderate pain, fever reduction, dysmenorrhea, inhibition of platelet aggregation, which protects against ischemic stroke and myocardial infarction(asprin)
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What are adverse effects of nonopioid analgesics | GI discomfort, Gi bleeding due to prolonged use, Renal dysfunction, Increased risk of Heart attack and Stroke, headaches, dizziness, tinnitus, sweating, Reye syndrome when children are given aspirin for fevers, aspirin toxicity
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What are contradictions for nonopioid analgesics | Pregnancy(D), Peptic ulcer disease, Bleeding disorders, hypersensitivity to aspirin, children and ado. who have chickenpox or influenza, older adults who smoke or alcoholism
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How long should iv ibuprofen be infused for | 30 min
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what is an agonist | it attaches to a receptor and produces a response
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what is an antagonist | it attaches to a receptor site and prevents a response
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