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Nonopioid Analgecics

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Question
Answer
What actions do nonopioid analgesics have   anti-inflammatory, antipyretic, and analgesic action  
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Examples of First generation NSAIDs Cox 1 and cox 2 inhibitors   aspirin, ibuprofen, naproxen, indomethacin, diclofenac, ketorolac, meloxicam  
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Example of second generation NSAIDs cox 2 inhibitors   celecoxib  
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What are the therapeutic uses   inflammation suppression, analgesia for mild-moderate pain, fever reduction, dysmenorrhea, inhibition of platelet aggregation, which protects against ischemic stroke and myocardial infarction(asprin)  
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What are adverse effects of nonopioid analgesics   GI discomfort, Gi bleeding due to prolonged use, Renal dysfunction, Increased risk of Heart attack and Stroke, headaches, dizziness, tinnitus, sweating, Reye syndrome when children are given aspirin for fevers, aspirin toxicity  
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What are contradictions for nonopioid analgesics   Pregnancy(D), Peptic ulcer disease, Bleeding disorders, hypersensitivity to aspirin, children and ado. who have chickenpox or influenza, older adults who smoke or alcoholism  
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How long should iv ibuprofen be infused for   30 min  
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what is an agonist   it attaches to a receptor and produces a response  
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what is an antagonist   it attaches to a receptor site and prevents a response  
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