Reproduction
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| HFG Syndrome | Bicornuate uterus/hypospadias, deformed hands, feet. HomeoboxA-13 mutation.
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| XXY | Abnormal Leydig & Sertoli->High FSH & LH. Barr Body
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| Hydatiform Mole | Empty egg-> Diploid sperm contribution (Complete), tripoid or tetraploid (Partial) w/ greater development. Coriocarcinoma precursor.
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| Abruptio placentae | Placental detachment: PAINFUL bleeding: associated w/DIC, smoking, HTN, Cocaine
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| Placenta accretia | Placental attachment to myometrium. MASSIVE postpartum bleeding. Assoc w/ C-Sec & Inflammation
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| Adenomyositis | Endometriosis within the myometrium
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| Polycystic Ovarian Syndrome | Amenorrhea, infertility, obesity, hirsutism. Low FSH (semi-developed follicles), high LH->high Testosterone. Insulin resistance, endometrial cancer. Tx: Wt Loss, OCP/Gonadotropin analog, clomiphene
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| Follicular Ovarian Cyst | Unruptured graafian follicle. Associated w elevated Estrogen/endometrial hyperplasia
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| Corpus Luteum Cyst | Hemorrhage into persistent corpus luteum. Associated w/ menstrual irregularity
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| Theca-Lutein Cyst | Bilateral. Due to gonadotropin stimulation. Associated w/ Choriocarcinomas & moles
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| Chocolate Ovarian Cyst | Ovarian endometriosis ->blood containing cyst. Cycle-associated.
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| Ovarian germ cell tumors | Yolk sac, Choriocarcinoma, Dysgerminoma, Teratoma (MATURE [only non-malignant one], Struma ovarii, immature)
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| Ovarian non-germ cell tumors | CA-125. BRCA1, HNPCC Serous Cystadenomas/Cystadenocarcinomas, Mucinous cystadenomas/cystadenocarcinomas, Brenner Tumor, Fibromas, Granulosa Cell tumor, Krukenberg tumor
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| Serous Cystadenoma/Cystadenocarcinoma | 70% of ovarian tumors. Bilateral, fallopian tube-like epithelium. Benign/Malignant.
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| Mucinous Cystadenoma/Cystadenocarcinoma | Cysts lined w/ mucous secreting epithelium. Benign/Malignant
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| Brenner Tumor | Benign, Bladder-like
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| Meig's Syndrome Triad | Ovarian fibromas, ascites, hydrothorax. Pulling sensation in groin
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| Granulosa Cell Tumor | Estrogen secreting (Precocious puberty). Endometrial hyperplasia ->->carcinomas. Call-Exner Bodies: Follicles w/ eosinophilic secretions
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| Krukenberg tumor | GI metastasis to ovary: Mucin-secreting signet cell adenocarcinoma
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| Vaginal Clear cell adenocarcinoma | DES exposure
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| Yolk sac (Ovarian & Testicular) | Alpha Fetoprotein. Male:Schiller Duval Bodies of primitive glomeruli
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| Choriocarcinoma | Ovarian & Testicular. Beta hCG. Women: increased theaca-lutein cysts.
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| Dysgerminoma | hCG
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| Ductal Papilloma | Serous +/- blood, unilobular & unilateral. Slight malignancy risk.
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| Ductal Carcinoma (In-Situ) | Non-invasive, remains within basement membrane. ->Comedocarcinoma.
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| Fibroadenoma | Young ppl. Small circumscribed mobile mass. Enlarge in pregnancy. Non-cancerous
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| Phyllodes Tumor | Large, clefted leaf-like. Malignant potential.
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| Invasive Ductal Carcinoma | Spiculated firm fibrosis. Most common & worst prognosis
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| Invasive Lobular Breast Carcinoma | "Indian Lines" multiple, +/-bilateral
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| Comedocarcinoma | Ductal, necrosis. Higher grade DCIS. Diffuse paplapble mass.
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| Paget's Disease | Ductal epithelium spread. Red nipple. Large clear cells.
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| Inflammatory Breast Carcinoma | Lymphatic involvement. Peau d'orange.
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| Breast Cancer Risk Factors | Early menarche. Late 1st pregnancy, late menopaus. Family. BRCA1/2, HNPCC, erb-B2
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| XYY | Antisocial
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| XO | +/- Mosaic form. Leydig & Theca cell dysgenesis-> high FSH, LH. Horseshoe kidney, bicuspid Aortic valve. High palate. Preductal coarct.
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| Testicular Germ Cell Tumors | Seminoma, Embryonal Carcinoma, Yolk Sac, Choriocarcinoma, Teratoma
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| Non-Germ Cell Tumors (Sex cord) | Leydig Cell, Sertoli Cell, Testicular Lymphoma.
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| Leydig Cell Tumor | Reinke crystals. Androgens-> Gynecomastia, precocious puberty
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| Seminoma | Painless. Watery cytoplasm. Radiosensitive & late metastasis. Good prognosis.
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| Embyonal Carcinoma | Painful. Poor prognosis. Glandular/papillary.
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| Bowden Disease/Erythroplasia of Queyrat | SINGLE erythematous plaque on shaft or scrotum/glans. Risk of carcinoma.
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| Reinke Crystals | Leydig Cell Tumor
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| Call-Exner Bodies | Theca Cell Tumor
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Created by:
Kyle Tiemeier
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