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antidepressants

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Answer
Antimanics are used in the treatment of   mood disorders  
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Lithium is the most commonly used drug for the treatment of   mania  
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Lithium is an element that is similar in chemical properties   to sodium  
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Sodium is required for   conduction of nerve impulses, but lithium interferes with nerve conduction.  
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Sodium range:   135-145  
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lithium works to ____ the reuptake of NE and Dop.   increase  
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Lithium takes how many weeks to fully work?   1-2 wks  
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Adequate sodium intake is necessary for proper...   urinary excretion of lith.  
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therapeutic blood levels range   0.5 to 1.5 mEq/L  
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lithium maintenance dose:   900-1200mg/day  
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lithium drug interactions:   haldol, diuretics  
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MOOD STABILIZERS:second best choice in the treatment of mania   are anticonvulsants  
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examples of anticonvulsants:   Depakote, GABApentin, Carbamazepine  
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3rd best choice:   Propranolol  
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Propranolol nursing considerations   do not give if pulse is below 60  
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exogenous   reactive depression-caused by external factors death or unemployment, loss  
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endogenous   caused by internal factors. Nobody ever has. Hard to diagnose. Chemical imbalance neurotransmitters. Can last for a long time. Postpartum. Get under control.  
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What is the role of serotonin?   moods, arousal levels, appetite, sleep disturbances (endogenous depression) main one have to restore  
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role of NE?   NE- cardiovascular system, fight or flight, moods  
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Drugs that can increase the level of norepinephrine or serotonin in the brain are useful in the treatment   OF DEPRESSION  
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antidepressants take   about 2 to 4 weeks to work fully in the body.  
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Monoamine Oxidase Inhibitors (MAOIs)   an enzyme found in most body cells.break down norepinephrine and serotonin  
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Why is this bad in relation to depression?   We need Serotonin and NE to increase  
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Tyramine can produce a massive release of NE, which can result in   hypertensive crisis or cerebral stroke.  
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Which foods must one avoid?   Ginseng, chocolate, beer, cheese, pickles, olives, wine and avocado  
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Side effects and adverse effects of MAOI:   dry mouth, urinary ret, constipation, blurred vision, hypotension, weight gain, and sex dysfunction. can produce liver damage.  
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Phenylzine (Nardil)   MAOI  
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Tricyclic Antidepressants or (TCAs)   block the reuptake of norepinephrine and serotonin.  
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anticholinergic sx:   dry mouth, constipation, urinary ret, tachycardia, and hypertension.  
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TCAs:   Nortriptyline (Aventyl) Amitriptyline (Elavil) Doxepin (Sinequan) Imipramine (Tofranil)  
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Selective Serotonin Reuptake Inhibitors (SSRIs)   block the reuptake and inactivation of serotonin in the brain.  
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Sertraline (Zoloft)   dosage: 50-200mgPO  
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Fluoxetine (Prozac)   dosage: 20-40mgPO  
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Prozac does not mix well   anticoagulants and benzodiazepines (Xanax).  
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Prozac is also effective in the treatment   OCD  
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Side and Adverse effects of (SSRIs):   nausea, diarrhea, dry mouth, anorexia, and GI disturbances.  
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Adverse effects OF SSRIs   1) Weight loss 2) Insomnia 3) Tremors 4) Nervousness  
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Second group of SSRIs are the atypicals.   Bupropion (Wellbutrin) & Venlafaxine (Effexor)  
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atypical SSRI Duloxetine (Cymbalata)   If you have depression, diabetic neuropathy pain, fibromyalgia, generalized anxiety disorder, or chronic pain, a healthcare provider may prescribe:  
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TCAs may also produce effects in   heart and liver  
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TCAs are safer comapred to...   MAOIs  
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