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Test 2 Advanced patho

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Question
Answer
Shock   The physiologic state characterized by a reduction of systemic tissue perfusion resulting in decreased oxygen delivery to the cells and tissues.  
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Systemic Tissue perfusion   Cardiac output and systemic vascular resistance CO = HR x SV Stroke volume is related to preload, myocardial contractility and after load. Affected by vessel length, blood viscosity and vessel diameter  
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Cardinal Symptoms of Shock   Hypotension: absolute SBP <90 or Relative: a decrease in SBP >40 Oliguria: vol. depletion, shunting to kidney Altered mental status: agitation, confusion, coma Cool clammy skin: vaso constriction Metabolic acidosis: lactate build up  
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Prognosis of Shock   Depends on type and severity Time of onset of initial treatment Co-morbid states, development of complications Even with treatment: septic and cardiogenic >50% mortality. Untreated: fatal  
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States of Shock   Preshock Shock End organ dysfunction  
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Preshock   Warm shock: decreased afterload (SVR) Increased cardiac output/cardiac index Decreased blood pressure Sympathetic response  
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Shock: cold shock   Decreased CO Elevated SVR Decreased perfusion Sympathetic response Hypothermia  
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End Organ Dysfunction   Multiple organ dysfunction syndroms  
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