Comprehensive Pharm 5
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| class thioridizine | typical antipsychotic
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| class haloperidol | typical antipsychotic
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| class fluphenazine | typical antipsychotic
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| class chlorpromazine | typical antipsychotic
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| class clozapine | atypical antipsych
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| Class olazapine | atypical antipsych
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| class risperidone | atypical antipsych
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| class fluoxetine | ssri
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| class paroxetine | ssri
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| class sertraline | ssri
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| class citalpram | ssri
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| class imipramine | tca
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| class amitriptyline | tca
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| class desipramine | tca
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| class nortiptyline | tca
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| class clomipramine | tca
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| class doxepin | tca
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| class buprorpion | heterocyclic
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| class venlafaxine | heterocyclic
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| class mirtazapine | heterocyclic
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| class maprotiline | heterocyclic
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| class trazadone | heterocyclic
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| class phenylzine | maoi
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| class tranylcypromine | maoi
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| toxicity associated with ssri | gi distress anorgasmi a seratonin syndrome if given with maoi
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| sx of seratonin syndrome | hyperthermia muscle rigidity cv collapse
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| how long does it take for antidepressants to work | 2-3 wks
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| side effects of tca | sedation alpha-blocking effects atropine like effects (tachy, urinary retention)
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| which generation of tca s have more anticholinergic effects? give an example of the drug | 3rd amitryptyline
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| which tca is least sedating | desipramine
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| toxicity assocaited with tcas | tri-c's convulsions coma cardiotoxicity respiratory depression hyperpyrexia confusion and hallucination in elderly (d/t anticholinergic effects)
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| which class of drugs is used to treat alcohol w/d | benzos
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| which class of drugs is used to treat anorexia/bulemia | ssri
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| which drugs are used to treat anxiety | buspirone benzos/barbiturates (take a shorter time to work) MAOI
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| which drugs are ssris? | paroxetine fluoxetine sertriline citalopram
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| which class of drugs is used to treat atypical depression | maoi
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| which class of drugs is used ot treat bipolar d/o | lithium carbamazepine valproic acid
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| which drugs are used to treat depression | ssri tca
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| which drugs are used to treat depression with insomnia | trazadone mirtazapine
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| which drugs are used totreat OCD | climipramine ssri olanzepine
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| which drugs are used to treat panic d/o | tca buspirone
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| toxicity associated with maois | hypertensive crisis associated with ingesting wine/cheese (tyramine)
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| drug interactions assicated with maois | TCA and ssri (--> both cause seratonin syndrome)
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| MOA venlafaxine | inhibits 5HT, NorE,
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| toxicity of venlafaxine | stimulant effects sedation nausea constipation increased BP
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| MOA mirtazapine | alpha-2 antagonist (increased release of NorE and 5HT) and potent 5HT2, 3 receptor antagonist
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| toxicity of mirtazapine | sedation increased appetite weight gain dry mouth
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| moa maprotiline | blocks NorE reuptake
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| toxicity of maprotiline | sedation orthostatic hypotension
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| moa trazadone | inhibits 5HT reuptake
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| toxicity of trazadone | sedation nausea priapism postural hypotension
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| MOA dantroline | blocks the release of ca from SR of skeletal muscles
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| uses of dantroline | nms malignant hyperthermia
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| wha tcan cause malignant hyperthermia | inhalation of anesthetics and succinylcholine
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| what are the different types of NM blocking agents | depolarizing and nondepolarizing
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| ex of a depolarizing NM blocking agent | succinylcholine
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| ex of nondepolarizing NM blockign agent | anything with a "cur" in it
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| uses of NM blockign agents | to paralyze muscles in surgery or mechanical ventilation
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| what are the 2 phases of depolarizing NM blockade? | 1: continuous depolarization 2: gradual repolarization with resistance
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| how do you reverse the depolarizing blockade at phase 1? phase 2? | administer cholinesterase inhibitors (eg: neostigmine or physostimine) during PHASE
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| how do you reverse the non-depolarizing blockade? | cholinesterase inhibitors (eg: neostigmine, edrophonium)
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