Lecture 2
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Define virulence | an organism's ability to cause an infection and establish disease (pathogenicity); attributed to differences in genomes
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| Define infection | Bacteria capable of causing disease becomes established within the host.
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| Define colonization | Persistence within the host of a disease causing bacterium without symptoms (asymptomatic carriers)
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| Define disease | Infection that produces symptoms.
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| Two categories of virulence factors | Promotion of colonization (invasion into the host) and agents that cause damage to the host (toxins)
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| A-B Toxins | Separate peptides that mediate host binding (B) and toxin activity (A), eg. Diphtheriae, cholerae, and tetanus
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| Membrane disrupting toxins | Hemolysins and phospholipases, eg. a-toxin of C. perfingens.
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| Superantigens | Act by stimulating T-cells to release cytokines. eg. S. aureus -toxic shock protein.
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| AB Toxins do this to inactive proteins | Ribosylate
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| Bactericidal | Permanent loss of replication
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| Bacteriostatic | Temporary loss of replication
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| Minimum Inhibitory Concentration (MIC) | Lowest concentration that inhibits growth
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| Minimum Bactericidal Concentration (MBC) | Lowest concentration that reduces growth by 99 %
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Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
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Created by:
Krafty
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