Leukemia, Lymphoma and Multiple Myeloma
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| Defined as a group of malignant leukocyte disorders | Leukemia
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| Begins in bone marrow and spreads to blood and lymphatic tissue | Leukemia
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| This type of cell differentiates to form basophils, eosinophils and neutrophils | Myeloblasts
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| This type of cell differentiates to form lymphocytes | Lymphoblasts
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| This leukemia classification has a rapid onset and course and involves proliferation of immature blast cells | Acute
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| This leukemia classification has a gradual onset and involves mature forms of WBCs | Chronic
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| This is the most common leukemia in adults | Chronic lymphocytic leukemia
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| What gender is affected most by chronic lymphocytic leukemia? | Men
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| This type of leukemia involves an accumulation of small, mature-appearing, non-functional lymphocytes that can get jammed-up in the spleen (splenomegaly), liver (hepatomegaly) and lymph nodes (lymphadenopathy) | Chronic lymphocytic leukemia
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| Prior chemotherapy for a different cancer treatment increases the risk of developing this type of leukemia 9-10 years after initial treatment | Acute myelogenous leukemia
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| Bone marrow hyperplasia results with this type of leukemia where the myeoblasts are dividing so rapidly and take up space in the bone marrow thus displacing other cells like RBCs and platelets | Acute myelogenous leukemia
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| Fatigue, weakness, fever and infections and abnormal bleeding and anemia are signs/symptoms of this type of leukemia | Acute meylogenous leukemia
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| This is the most common leukemia that occurs in children | Acute lymphocytic leukemia
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| This type of leukemia involves the proliferation of immature lymphocytes | Acute lymphocytic leukemia
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| When the onset of acute lymphocytic leukemia is abrupt, these are the most common presenting symptoms | Bleeding and/or fever
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| When the onset of acute lymphocytic leukemia is insidious, these are the most common presenting symptoms | Fatigue, bone/joint pain, bleeding
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| This type of leukemia begins with a chronic stable phase which can abruptly manifest with an acute blastic phase that results in a quick death | Chronic myelogenous leukemia
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| This type of leukemia involves mature neoplastic granulocytes that proliferate in bone marrow and move to peripheral circulation and infiltrate the liver and spleen | Chronic myelogenous leukemia
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| The genetic marker for this type of leukemia is the Philadelphia chromosome | Chronic myelogenous leukemia
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| The peak incidence of this type of leukemia is age 60-70 years of age | Acute myelogenous leukemia
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| The peak incidence of this type of leukemia is 45 years of age | Chronic myelogenous leukemia
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| This causes the bone pain associated with leukemia | Accumulation of non-functional WBCs inside of bone marrow
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| Besides bone pain, other manifestations of this disease include anemia, thrombocytopenia, hepatomegaly, splenomegaly, lymphadenopathy, meningeal irritation and oral lesions | Leukemia
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| Diagnostics of leukemia include bone marrow biopsy and peripheral blood smear that is read by whom? | Pathologist
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| Minimizing drug toxicity and attacking various stages of the cancer cell cycle are the reasons for this type of chemotherapy in the treatment of leukemia | Combination chemotherapy
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| Avoiding IM and SubQ injections, avoiding valsalva maneuver, controlling bleeding, checking labs and administering platelets and blood products are interventions aimed to manage this side effect of leukemia treatment | Thrombocytopenia (less than 150,000)
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| Assessing for infection, taking blood cultures, using antibiotics and antifungals, hand washing, environmental controls, protective isolation and administering neupogen are interventions aimed to manage this side effect of leukemia treatment | Neutropenia (less than 1,000/mm3)
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| Defined as the proliferation of abnormal lymphocytes | Lymphoma
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| Hodgkin's and non-Hodgkin's are the two types of this disease | Lymphoma
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| Of Hodgkin's or non-Hodgkin's, which one is the "better" one to have if you have to have one? | Hodgkin's
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| This the hallmark sign of Hodgkin's lymphoma as obtained with an excisional lymph node biopsy | Reed-Sternberg cells
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| These cells are described as abnormal, giant, multinucleated cells in lymph nodes | Reed-Sternberg cells
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| Which gender is affected most with Hodgkin's lymphoma? | Men
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| Where do B-lymphocytes mature? | In the bone marrow
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| Where do T-lymphocytes mature? | In the thymus
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| This disease is considered a B-lymphocyte malignancy | Hodgkin's leukemia
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| This disease has a bimodal incidence at 15-35 years and then again > 50 years | Hodgkin's leukemia
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| Where does Hodgkin's leukemia begin? | In the cervical lymph nodes
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| Fever, night sweats and weight loss are the "B symptoms" of these diseases | Hodgkin's and non-Hodgkin's lymphoma
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| Alcohol induced pain at the site of the malignancy is a manifestation of this disease | Hodgkin's lymphoma
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| This stage for Hodgkin's and non-Hodgkin's lymphoma involves one malignant lymph node | Stage 1 (would be cervical lymph node in Hodgkin's lymphoma)
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| This stage for Hodgkin's and non-Hodgkin's lymphoma involves two areas on the same side of the diaphragm | Stage 2
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| This stage for Hodgkin's and non-Hodgkin's lymphoma involves two or more nodes on both sides of the diaphragm | Stage 3
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| This stage for Hodgkin's and non-Hodgkin's lymphoma involves widespread and diffuse involvement | Stage 4
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| The combination chemotherapy for Hodgkin's lymphoma involves ABVD; what does the "A" stand for? | Adriamycin
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| The combination chemotherapy for Hodgkin's lymphoma involves ABVD; what does the "B" stand for? | Bleomycin
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| The combination chemotherapy for Hodgkin's lymphoma involves ABVD; what does the "V" stand for? | Vinblastine
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| The combination chemotherapy for Hodgkin's lymphoma involves ABVD; what does the "D" stand for? | Dacarbazine
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| What is the 5-year survival rate for Hodgkin's lymphoma? | > 90%
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| This disease is considered a B or T lymphocyte malignancy | non-Hodgkin's lymphoma
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| Low-grade (indolent), intermediate grade (aggressive) and high grade (very aggressive) are the classifications of this disease | non-Hodgkin's lymphoma
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| The clinical manifestations of painless enlarged lymph nodes, fever, night sweats and weight loss are called these type of symptoms that are associated with worse outcomes in both Hodgkin's and non-Hodgkin's lymphoma | B symptoms
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| This disease involves the infiltration of malignant plasma cells into the bone marrow resulting in bone destruction | Multiple myeloma
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| Average onset at 65 years, men>women, and African Americans>Caucasians describes what disease? | Multiple myeloma
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| M protein is a diagnostic marker for this disease and is found in both the blood and urine | Multiple myeloma
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| This disease involves excessive production of cytokines (interleukins) | Multiple myeloma
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| Skeletal pain is the most common manifestation of this disease | Multiple myeloma
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| Where are the most common sites of skeletal pain in multiple myeloma? | Pelvis, spine and ribs
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| Is hypercalcemia or hypocalcemia a manifestation of multiple myeloma? | Hypercalcemia that can lead to renal failure
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| Bone erosion, fractures and myeloma cells can be seen using these diagnostic tests | X-ray, CT scan, MRI and PET scan
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| Bence Jones protein is found in the urine of patients with this disease | Multiple myeloma
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| Beta-2 microglobulin and albumin are prognostic markers of this disease | Multiple myeloma
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| If the beta-2 microglobulin level is elevated and the albumin level is low, is this a better or worse prognosis for multiple myeloma? | Worse
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| Is there a cure for multiple myeloma? | No
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| Collaborative care for multiple myeloma focuses on what? | Improving quality of life
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| Hydration via IV fluids is a nursing intervention for multiple myeloma; what is the output goal/day? | 1.5 to 2 L urine output/day
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| Treating the pain associated with the release of cytokines in multiple myeloma involves a combination of what medications? | NSAIDs, acetaminophen, and opioids
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| Getting them from two different sites 30 minutes apart from each other is the protocol for obtaining what? | Blood cultures
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