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Nur-354

Leukemia, Lymphoma and Multiple Myeloma

TermDefinition
Defined as a group of malignant leukocyte disorders Leukemia
Begins in bone marrow and spreads to blood and lymphatic tissue Leukemia
This type of cell differentiates to form basophils, eosinophils and neutrophils Myeloblasts
This type of cell differentiates to form lymphocytes Lymphoblasts
This leukemia classification has a rapid onset and course and involves proliferation of immature blast cells Acute
This leukemia classification has a gradual onset and involves mature forms of WBCs Chronic
This is the most common leukemia in adults Chronic lymphocytic leukemia
What gender is affected most by chronic lymphocytic leukemia? Men
This type of leukemia involves an accumulation of small, mature-appearing, non-functional lymphocytes that can get jammed-up in the spleen (splenomegaly), liver (hepatomegaly) and lymph nodes (lymphadenopathy) Chronic lymphocytic leukemia
Prior chemotherapy for a different cancer treatment increases the risk of developing this type of leukemia 9-10 years after initial treatment Acute myelogenous leukemia
Bone marrow hyperplasia results with this type of leukemia where the myeoblasts are dividing so rapidly and take up space in the bone marrow thus displacing other cells like RBCs and platelets Acute myelogenous leukemia
Fatigue, weakness, fever and infections and abnormal bleeding and anemia are signs/symptoms of this type of leukemia Acute meylogenous leukemia
This is the most common leukemia that occurs in children Acute lymphocytic leukemia
This type of leukemia involves the proliferation of immature lymphocytes Acute lymphocytic leukemia
When the onset of acute lymphocytic leukemia is abrupt, these are the most common presenting symptoms Bleeding and/or fever
When the onset of acute lymphocytic leukemia is insidious, these are the most common presenting symptoms Fatigue, bone/joint pain, bleeding
This type of leukemia begins with a chronic stable phase which can abruptly manifest with an acute blastic phase that results in a quick death Chronic myelogenous leukemia
This type of leukemia involves mature neoplastic granulocytes that proliferate in bone marrow and move to peripheral circulation and infiltrate the liver and spleen Chronic myelogenous leukemia
The genetic marker for this type of leukemia is the Philadelphia chromosome Chronic myelogenous leukemia
The peak incidence of this type of leukemia is age 60-70 years of age Acute myelogenous leukemia
The peak incidence of this type of leukemia is 45 years of age Chronic myelogenous leukemia
This causes the bone pain associated with leukemia Accumulation of non-functional WBCs inside of bone marrow
Besides bone pain, other manifestations of this disease include anemia, thrombocytopenia, hepatomegaly, splenomegaly, lymphadenopathy, meningeal irritation and oral lesions Leukemia
Diagnostics of leukemia include bone marrow biopsy and peripheral blood smear that is read by whom? Pathologist
Minimizing drug toxicity and attacking various stages of the cancer cell cycle are the reasons for this type of chemotherapy in the treatment of leukemia Combination chemotherapy
Avoiding IM and SubQ injections, avoiding valsalva maneuver, controlling bleeding, checking labs and administering platelets and blood products are interventions aimed to manage this side effect of leukemia treatment Thrombocytopenia (less than 150,000)
Assessing for infection, taking blood cultures, using antibiotics and antifungals, hand washing, environmental controls, protective isolation and administering neupogen are interventions aimed to manage this side effect of leukemia treatment Neutropenia (less than 1,000/mm3)
Defined as the proliferation of abnormal lymphocytes Lymphoma
Hodgkin's and non-Hodgkin's are the two types of this disease Lymphoma
Of Hodgkin's or non-Hodgkin's, which one is the "better" one to have if you have to have one? Hodgkin's
This the hallmark sign of Hodgkin's lymphoma as obtained with an excisional lymph node biopsy Reed-Sternberg cells
These cells are described as abnormal, giant, multinucleated cells in lymph nodes Reed-Sternberg cells
Which gender is affected most with Hodgkin's lymphoma? Men
Where do B-lymphocytes mature? In the bone marrow
Where do T-lymphocytes mature? In the thymus
This disease is considered a B-lymphocyte malignancy Hodgkin's leukemia
This disease has a bimodal incidence at 15-35 years and then again > 50 years Hodgkin's leukemia
Where does Hodgkin's leukemia begin? In the cervical lymph nodes
Fever, night sweats and weight loss are the "B symptoms" of these diseases Hodgkin's and non-Hodgkin's lymphoma
Alcohol induced pain at the site of the malignancy is a manifestation of this disease Hodgkin's lymphoma
This stage for Hodgkin's and non-Hodgkin's lymphoma involves one malignant lymph node Stage 1 (would be cervical lymph node in Hodgkin's lymphoma)
This stage for Hodgkin's and non-Hodgkin's lymphoma involves two areas on the same side of the diaphragm Stage 2
This stage for Hodgkin's and non-Hodgkin's lymphoma involves two or more nodes on both sides of the diaphragm Stage 3
This stage for Hodgkin's and non-Hodgkin's lymphoma involves widespread and diffuse involvement Stage 4
The combination chemotherapy for Hodgkin's lymphoma involves ABVD; what does the "A" stand for? Adriamycin
The combination chemotherapy for Hodgkin's lymphoma involves ABVD; what does the "B" stand for? Bleomycin
The combination chemotherapy for Hodgkin's lymphoma involves ABVD; what does the "V" stand for? Vinblastine
The combination chemotherapy for Hodgkin's lymphoma involves ABVD; what does the "D" stand for? Dacarbazine
What is the 5-year survival rate for Hodgkin's lymphoma? > 90%
This disease is considered a B or T lymphocyte malignancy non-Hodgkin's lymphoma
Low-grade (indolent), intermediate grade (aggressive) and high grade (very aggressive) are the classifications of this disease non-Hodgkin's lymphoma
The clinical manifestations of painless enlarged lymph nodes, fever, night sweats and weight loss are called these type of symptoms that are associated with worse outcomes in both Hodgkin's and non-Hodgkin's lymphoma B symptoms
This disease involves the infiltration of malignant plasma cells into the bone marrow resulting in bone destruction Multiple myeloma
Average onset at 65 years, men>women, and African Americans>Caucasians describes what disease? Multiple myeloma
M protein is a diagnostic marker for this disease and is found in both the blood and urine Multiple myeloma
This disease involves excessive production of cytokines (interleukins) Multiple myeloma
Skeletal pain is the most common manifestation of this disease Multiple myeloma
Where are the most common sites of skeletal pain in multiple myeloma? Pelvis, spine and ribs
Is hypercalcemia or hypocalcemia a manifestation of multiple myeloma? Hypercalcemia that can lead to renal failure
Bone erosion, fractures and myeloma cells can be seen using these diagnostic tests X-ray, CT scan, MRI and PET scan
Bence Jones protein is found in the urine of patients with this disease Multiple myeloma
Beta-2 microglobulin and albumin are prognostic markers of this disease Multiple myeloma
If the beta-2 microglobulin level is elevated and the albumin level is low, is this a better or worse prognosis for multiple myeloma? Worse
Is there a cure for multiple myeloma? No
Collaborative care for multiple myeloma focuses on what? Improving quality of life
Hydration via IV fluids is a nursing intervention for multiple myeloma; what is the output goal/day? 1.5 to 2 L urine output/day
Treating the pain associated with the release of cytokines in multiple myeloma involves a combination of what medications? NSAIDs, acetaminophen, and opioids
Getting them from two different sites 30 minutes apart from each other is the protocol for obtaining what? Blood cultures
Created by: ssbourbon