Adverse effects of medications
Help!
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| What drugs cause Cardiovascular Atropine-like side effects | Tricyclics
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| What drugs cause Cardiac toxicity | Doxorubicin (Adriamycin), daunorubicin
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| What drugs cause Coronary vasospasm | Cocaine
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| What drugs cause Cutaneous flushing | Niacin, Ca2+ channel blockers, adenosine, vancomycin
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| What drugs cause Torsades des pointes | Class III (sotalol), class IA (quinidine), cisapride
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| What drugs cause Agranulocytosis | Clozapine, carbamazepine, colchicine
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| What drugs cause Aplastic anemi | Chloramphenicol, benzene, NSAIDs
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| What drugs cause Gray baby syndrome | Chloramphenicol
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| What drugs cause Hemolysis in G6PD-deficient patients | IS PAIN isoniazid (INH), Sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin
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| What drugs cause Thrombotic complications | OCPs (e.g., estrogens and progestins)
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| What drugs cause Cough | ACE inhibitors
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| What drugs cause Pulmonary fibrosis | Bleomycin, amiodarone, busulfan
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| What drugs cause Acute cholestatic ;hepatitis | Macrolides
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| What drugs cause Focal to massive ;hepatic necrosis | Halothane, valproic acid, acetaminophen, Amanita phalloides
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| What drugs cause Hepatitis | INH
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| What drugs cause Pseudomembranous ;colitis | Clindamycin, ampicillin
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| What drugs cause Gynecomastia | (Some Drugs Create Awesome, Excellent Knockers) Spironolactone, Digitalis, Cimetidine, Alcohol chronicuse, Estrogens, Ketoconazole
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| What drugs cause Hot flashes | Tamoxifen
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| What drugs cause Gingival hyperplasia | Phenytoin
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| What drugs cause Osteoporosis | Corticosteroids, heparin
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| What drugs cause Photosensitivity | (SAT for a photo) Sulfonamides, Amiodarone, Tetracycline
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| What drugs cause SLE-like syndrome | (it’s not HIPP to have lupus)
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| What drugs cause Tendonitis, tendon rupture, and cartilage damage (kids) | Fluoroquinolones
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| What drugs cause Fanconi’s syndrome | Expired tetracycline
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| What drugs cause Interstitial nephritis | Methicillin
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| What drugs cause Hemorrhagic cystitis | Cyclophosphamide, ifosfamide
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| What drugs cause Cinchonism | Quinidine, quinine
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| What drugs cause Diabetes insipidus | Lithium, demeclocycline
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| What drugs cause Tardive dyskinesia | Antipsychotics
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| What drugs cause Disulfiram-like reaction | Metronidazole, certain cephalosporins, procarbazine, sulfonylureas
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| What drugs cause Nephrotoxicity & neurotoxicity | Polymyxins
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| What drugs cause Nephrotoxicity & ototoxicity | Aminoglycosides, loop diuretics, cisplatin
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| P-450 Inducers | "Queen Barb takes Phenphen ;and Refuses Greasy Carved Steak" Quinidine (can inhibit too), Barbiturates, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, St. John’s wort
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| P-450 Inhibitors | Inhibitors Stop CyberKids from Eating Grapefruit. Isoniazid; Sulfonamides; Cimetidine; Ketoconazole; Erythromycin; Grapefruit juice
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| Iron Poisioning Mech | Cell death due to peroxidation of membrane lipids
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| Iron Poisioning Symps | acute gastric bleeding chronic metabolic acidosis, scarring (leading to GI obstruction)
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| Inhibited by Disulfiram | Acetaldehyde dehydrogenase
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| Competitive substrates for Alcohol dehydrogenase | Ethylene glycol, Methanol, Ethanol
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| Ethylene glycol toxicity | Acidosis, nephrotoxicity
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| Methanol toxicity | Severe acidosis, retinal damage
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| Ethanol toxicity | Nausea, vomiting, headache, hypotension
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| The toxicity of which alcoholic compound causes Acidosis, nephrotoxicity | Ethylene glycol
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| The toxicity of which alcoholic compound causes Severe acidosis, retinal damage | Methanol
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| The toxicity of which alcoholic compound causes Nausea, vomiting, headache, hypotension | Ethanol
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| Too much Ethylene glycol can cause what compound to build up? | Build up of Oxalic acid
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| Too much Methanol can cause what compound to build up? | Build up of Formaldehyde;and formic acid
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| Too much EtOH can cause what compound to build up? | Build up of Acetaldehyde
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| If you have a buildup of Oxalic acid, what type of alcohol toxicity is it? | Ethylene glycol
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| If you have a buildup of formaldehyde, what type of alcohol toxicity is it? | Methanol
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| If you have a buildup of acetaldehyde, what type of alcohol toxicity is it? | Ethanol
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| Drugs that cause problems in patients with sulfa allergies | Celecoxib, furosemide, thiazides, TMPSMX, sulfonyureas, sufasalazine
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| Herbal agents Clinical uses and Toxicities Echinacea | Common cold; no major toxicities
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| Herbal agents Clinical uses and Toxicities Ephedra | Same as ephedrine; CNS and cardiovascular stimulation; arrhythmias, stroke, and seizures at high doses
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| Herbal agents Clinical uses and Toxicities Feverfew | Used for migraine. Adv: mouth ulcers, antiplatelet actions
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| Herbal agents Clinical uses and Toxicities Ginkgo | Used for Intermittent claudication. Adv: anxiety, insomnia, antiplatelet actions
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| Herbal agents Clinical uses and Toxicities Kava | Used for Chronic anxiety. Adv: sedation, ataxia, hepatotoxicity, phototoxicity, dermatotoxicity
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| Herbal agents Clinical uses and Toxicities Milk thistle | Used for Viral hepatitis. Adv: Loose stools
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| Herbal agents Clinical uses and Toxicities Saw palmetto | Used for Benign prostatic hyperplasia. Adv: ↓ libido, hypertension
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| Herbal agents Clinical uses and Toxicities St. John’s wort | Used for Mild to moderate depression. Adv: phototoxicity; serotonin syndrome;with SSRIs; induces P450 system
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| Herbal agents Clinical uses and Toxicities Dehydroepiandrosterone | Used for Symptomatic improvement in females with SLE or AIDS Androgenization (premenopausal women), estrogenic effects (postmenopausal), feminization (young men)
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| Herbal agents Clinical uses and Toxicities Melatonin | Used for Jet lag and insomnia. Adv: Sedation, suppresses midcycle LH, hypoprolactinemia
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